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Studying Pump Chemotherapy For Colorectal Cancer that Spread to the Liver
Hepatic arterial infusion (HAI) chemotherapy is a way to give cancer medicine straight into the liver using a small pump. The purpose of this study is to see if using this type of chemotherapy with regular chemotherapy can help people with colorectal cancer that has spread to the liver. Doctors will compare people who get both treatments to people who get only regular chemotherapy. The goal is to find out which treatment helps patients live longer and feel better.
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Helping Patients Manage Pain and Medicine After Surgery
The purpose of this research is to learn which of three treatments works best for helping people manage pain and use medicine after surgery. We also want to understand how pain, mood, and medicine use change after surgery. One of the treatments is a type of talk therapy called motivational interviewing, which may help people feel better and use less pain medicine. If you join the study, you will be placed into a group by chance-like flipping a coin. We are looking for volunteers who are scheduled for elective orthopedic surgery at Atrium Health Wake Forest Baptist.
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Studying Bone and Kidney Problems in Patients with Diabetes and Nerve Damage in their Feet
The purpose of this study is to learn how your kidneys affect the bones in your feet. We believe that healthy kidneys help keep your foot bones strong. Having diabetes and nerve damage can increase your chances of having kidney and foot problems. You will help us understand more about how they are related which will ultimately help us discover tests and treatments to prevent diabetes related foot problems.
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How Muscles Affect Walking as We Get Older
The purpose of this study is to find out why some older adults lose the ability to walk easily. Our researchers will test how changes in muscles, like strength and energy, affect walking and fitness. The goal is to find ways to help people stay active and independent as they age. To learn more, please visit our website here: www.sommastudy.com/somma2
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Aging Men's Health Pain Wellness and Lifestyle Women's Health Bones, Joints, Muscles
Studying a New Medicine to Prevent the Flu
The purpose of this study is to see if a new medicine called CD388 is safe and can help stop people from getting the flu. The study is for people who might get very sick from the flu. Researchers want to find out if CD388 works better than a look-alike shot with no medicine in it.
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Study of Two Medicines for Diabetes, Blood Pressure, and Heart Disease
The purpose of this study is to find out if taking two medicines together helps people with type 2 diabetes, high blood pressure, and heart disease. Our researchers will compare the medicines to a look-alike pill with no medicine inside. The goal is to see if the medicines can lower the chance of serious health problems like heart attacks or strokes.
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Treating Recurrent Small Cell Lung Cancer with a New Combination of Medications
The purpose of this study is to find a safe dose of the drugs pembrolizumab, tazemetostat and topotecan. We want to see if this combination will lower the chance of relapsed SCLC growing or spreading.
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Learning About Patient Experiences with HyQvia for Nerve Disease
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a long-term illness where the body's defense system attacks the nerves, making people feel weak and numb. This study aims to learn about the experiences of people with this disease who are using a medicine called HyQvia. We want to understand their symptoms, how the disease affects their daily lives, and their treatment experiences. The information we gather may help others in the future by improving our understanding of CIDP and making future research studies better.
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Comparing Two Treatments for People With Low Tumor Burden Follicular Lymphoma
The purpose of this study is to learn more about the drug mosunetuzumab. We want to see if this drug works better than the usual treatment for a type of cancer called low tumor burden follicular lymphoma.
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Testing Genes for Cystic Fibrosis Diabetes
The purpose of this study is to understand why people with cystic fibrosis get diabetes. Both diseases are caused by changes in DNA and other molecules in the blood. These changes can cause thick mucus in the pancreas, which damages cells that make insulin, leading to diabetes.
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Genetic Disorders Lung Health Children, Infants, Teen Health Diabetes
Testing Seizure Medicine for Kids
The purpose of this study is to test a liquid medicine called zonisamide for kids with seizures. We want to see how the medicine moves in the body and if it is safe. The study is for kids aged 1 month to 17 years who have partial-onset seizures.
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Testing an App for Better Sleep in Blood Cancer Patients
The purpose of this study is to test two wellness apps and see which one helps cancer patients sleep better. We want to find out how these apps affect sleep, immune health, and overall well-being of blood cancer patients during treatment.
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Comparing Two Drugs for Patients with Nodular Lymphocyte-predominant Hodgkin Lymphoma
The goal of this study is to test two different drugs for people with Nodular lymphocyte-predominant Hodgkin lymphoma. We want to see if the drug mosunetuzumab works better than the drug rituximab. We also want to see which drug helps people live longer without their disease getting worse. We are doing this study to find out if this new treatment is better or worse than the usual treatment for this type of lymphoma.
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Preventing Heart Disease in Psoriasis Patients
The purpose of this study is to test a new care program to help people with psoriasis lower their risk of heart disease. Examples of health risks are high cholesterol, high blood pressure, diabetes, and smoking that can lead to heart attacks or strokes. We want to see if a care coordinator can help patients manage their heart health better.
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Testing the Use of Daratumumab-Hyaluronidase for Treating T Cell Acute Lymphoblastic Leukemia
Sometimes after a patient with T cell acute lymphoblastic leukemia (T-ALL) has been treated with chemotherapy the leukemia remains at a very low level. This low level of leukemia is called minimal residual disease (MRD). People with MRD have a higher risk for leukemia coming back again. The purpose of this study is to find out if daratumumab and hyaluronidase can get rid of the MRD.
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Testing the Study Drug RGX-314 for Patients with Vision Loss
The purpose of this study is to learn more about the drug RGX-314. We want to see if this drug helps people with an eye disease called neovascular age-related macular degeneration. We also want to see if this drug can make their vision better or keep it from getting worse.
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How Damage to Blood Vessels in the Brain May Be Related to Thinking and Memory Problems Like Dementia
This study is being done to better understand how damaged blood vessels affect your thinking. This is not a treatment study.
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Studying New Vaccine for Stomach Flu
The purpose of this study is to learn more about a new vaccine called mRNA-1403. We want to see if the vaccine is safe and works well to prevent stomach flu caused by norovirus.
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Testing New Treatments for Large B-Cell Lymphoma
The purpose of this study is to test a new mix of three drugs called lenalidomide, mosunetuzumab, and polatuzumab vedotin. We want to see if these drugs are safe and helpful for people with a type of blood cancer called diffuse large B-cell lymphoma. This study is for patients whose cancer has come back or did not get better with other treatments. We also want to find the highest dose that is still safe for patients.
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Learning More About How HIV and Marijuana Affect the Brain
The purpose of this study is to learn more about how HIV and marijuana affect the brain. This will help us understand how changes in the brain affect the way we think and behave.
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Healthy Volunteers HIV/AIDS Substance Use (Alcohol, Illegal Drugs, Tobacco)