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Testing a New Study Device for Brain Aneurysms
A saccular intracranial aneurysm is a balloon-like bump in a brain blood vessel that can burst and cause big problems. The purpose of this study is to see if a new device is safe and helpful for treating this condition.
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Testing the Study Drug DFP-10917 for Patients with Acute Myeloid Leukemia
The purpose of this study is to find out more about the drug DFP-10917. We want to see if it is safe and helpful for treating people with acute myeloid leukemia.
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Testing the Study Drug Lutikizumab for Severe Skin Disease
Hidradenitis suppurativa is a skin problem that causes painful bumps and boils under the skin. The purpose of this study is to find out if the study drug lutikizumab is safe and useful for treating this skin problem.
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Using the TheraBionic Device to Treat Advanced Pancreatic Cancer
The purpose of this study is to find out how the TheraBionic device will affect pancreatic cancer. The TheraBionic device is a small portable device. We want to see if the device will prevent cancer growth.
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Learning the Best Ways to Treat Broken Bones and Reduce Future Fractures
The purpose of this study is to learn more about different ways to care for patients after they break a bone and to reduce your chances of having another fracture. We are looking for volunteers with a recent bone break and who have a regular doctor. They also must not have certain health conditions like cancer, severe kidney disease, or other bone diseases. The study team will provide more information.
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Testing the Study Drug Plozasiran for People with Hypertriglyceridemia
Hypertriglyceridemia is a condition where you have a high level of fat in your blood. The purpose of this study is to learn more about the study drug plozasiran for this condition. We want to find out if this study drug is safe and if it can help lower the fat levels in your blood.
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Managing Osteoarthritis Pain with Movement and Healthy Eating at Home
Osteoarthritis is a condition that causes pain and stiffness in the joints, often in the hips and knees. The purpose of this study is to find ways to help people with chronic pain due to this condition. We want to find a drug-free way to better manage symptoms through movement and healthy eating. The study is done entirely at home with virtual visits and assessments. The study team will provide more details.
Study Topics
Pain Arthritis, Lupus, and Autoimmune Disorders Bones, Joints, Muscles Weight, Metabolism, Nutrition
Studying Hair Loss and Family History
The purpose of this study is to learn more about a kind of hair loss called frontal fibrosing alopecia. We want to find out if a person's genes might cause this type of hair loss. We are also looking at family history, other hair problems, and treatments people have tried. This can help doctors find better ways to spot and treat this condition. We are looking for volunteers who have been diagnosed with frontal fibrosing alopecia.
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Studying Bone and Kidney Problems in Patients with Diabetes and Nerve Damage in their Feet
The purpose of this study is to learn how your kidneys affect the bones in your feet. We believe that healthy kidneys help keep your foot bones strong. Having diabetes and nerve damage can increase your chances of having kidney and foot problems. You will help us understand more about how they are related which will ultimately help us discover tests and treatments to prevent diabetes related foot problems.
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Using Metformin to Improve Sleep
This study wants to find out if a medicine called metformin can help people sleep better. It looks at how metformin affects a special kind of sleep that helps with learning and memory. The study also checks if metformin can fix daily activity and rest patterns that get messed up by health problems.
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Treating Recurrent Small Cell Lung Cancer with a New Combination of Medications
The purpose of this study is to find a safe dose of the drugs pembrolizumab, tazemetostat and topotecan. We want to see if this combination will lower the chance of relapsed SCLC growing or spreading.
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Learning About Patient Experiences with HyQvia for Nerve Disease
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a long-term illness where the body's defense system attacks the nerves, making people feel weak and numb. This study aims to learn about the experiences of people with this disease who are using a medicine called HyQvia. We want to understand their symptoms, how the disease affects their daily lives, and their treatment experiences. The information we gather may help others in the future by improving our understanding of CIDP and making future research studies better.
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Comparing Two Treatments for People With Low Tumor Burden Follicular Lymphoma
The purpose of this study is to learn more about the drug mosunetuzumab. We want to see if this drug works better than the usual treatment for a type of cancer called low tumor burden follicular lymphoma.
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Learning More About Living with Darier's Disease
Darier's disease is a rare skin condition that causes wart-like bumps. The purpose of this study is to learn more about the daily challenges faced by people with Darier's disease.
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Testing Genes for Cystic Fibrosis Diabetes
The purpose of this study is to understand why people with cystic fibrosis get diabetes. Both diseases are caused by changes in DNA and other molecules in the blood. These changes can cause thick mucus in the pancreas, which damages cells that make insulin, leading to diabetes.
Study Topics
Genetic Disorders Lung Health Children, Infants, Teen Health Diabetes
Testing the Study Drug SGN-MesoC2 for Advanced Solid Tumors
The purpose of this study is to learn more about a new study drug called SGN-MesoC2. We want to see if this study drug is safe and helpful for people with advanced solid tumors. We are looking for volunteers with certain types of cancer that have spread or cannot be removed by surgery. These types of cancers include ovarian cancer, lung cancer, pancreatic cancer, endometrial cancer, colorectal cancer, or mesothelioma.
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Testing Seizure Medicine for Kids
The purpose of this study is to test a liquid medicine called zonisamide for kids with seizures. We want to see how the medicine moves in the body and if it is safe. The study is for kids aged 1 month to 17 years who have partial-onset seizures.
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Studying How People Make Shopping Decisions at Retailers
The purpose of this study is to test how people make shopping decisions. The goal is to see how factors in the retail space impact purchase choices. This study is currently available for volunteers located in Chapel Hill, NC & Raleigh, NC.
Study Topics
Healthy Volunteers Substance Use (Alcohol, Illegal Drugs, Tobacco)
Testing an App for Better Sleep in Cancer Patients
The purpose of this study is to test two wellness apps and see which one helps cancer patients sleep better. We want to find out how these apps affect sleep, immune health, and overall well-being of blood cancer patients during treatment.
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Preventing Heart Disease in Psoriasis Patients
The purpose of this study is to test a new care program to help people with psoriasis lower their risk of heart disease. Examples of health risks are high cholesterol, high blood pressure, diabetes, and smoking that can lead to heart attacks or strokes. We want to see if a care coordinator can help patients manage their heart health better.
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