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Study of Two Medicines with Radiation for Adults with Sarcoma of the Arms or Legs
The purpose of this study is to learn more about a new treatment for patients with a type of cancer called sarcoma. We want to see if using two medicines, gemcitabine and docetaxel, along with radiation before surgery, can help stop or slow down the return of this cancer.
Study Topics
Improving Physical Function in Older Adults with Kidney Disease
The purpose of this study is to find out if two different programs can help older people with serious kidney problems. The first program involves exercise with quick movements 3 times per week for 12 weeks is about exercising quickly with weights, and the second program involves taking classes on how to live a healthy lifestyle once per week for 12 weeks is about living a healthy life. The study wants to see if older people enjoy these programs and if they can be done safely. We are looking for volunteers who live within 20 miles of the Reynolda Campus.
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Studying How Stress Affects Health in People Living with HIV
Many people living with HIV disease have stress in their lives that can negatively affect their health. The goal of this study is to understand how long-term stress changes how our brain and immune systems work. We also want to see how these changes affect our feelings, thoughts, and actions. By learning this, we hope to create better treatments for problems like depression and drug use. The study is open to individuals living with HIV.
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Improving COPD Care for Cancer Patients
Chronic obstructive pulmonary disease (COPD) is a lung disease that makes it hard to breathe because the airways are swollen and narrow. The purpose of this study is to create a new way to help cancer patients who also have COPD. We want to make their treatment easier and improve their care. Our study will look at how well this new care plan works.
Study Topics
Studying Hair Loss in Women of African Descent during Chemotherapy
The purpose of this study is to understand hair loss in African American women who are getting chemotherapy for breast cancer. We want to find out how common different types of hair loss are with chemotherapy. We also want to learn about the participants' health history, medical information, and hair styling habits.
Study Topics
Minority Health Skin, Hair, Nails Women's Health Cancer Cancer: Breast
Testing New Ulcerative Colitis Treatment
The purpose of this study is to learn more about a new study drug called Lutikizumab. We want to see if this study drug is safe and works well for treating moderate to severe ulcerative colitis. We will compare this study drug to another drug called Adalimumab.
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Arthritis, Lupus, and Autoimmune Disorders Stomach and Intestines
Learning More About Treating Myelofibrosis and Anemia with the Study Drug DISC-0974
Myelofibrosis is a rare blood disorder that can cause scar tissue to build up in the bone marrow. This can lead to anemia. Anemia can result in tiredness and general discomfort. The purpose of this study is to see who well the study drug DISC-0974 works for the treating myelofibrosis and anemia. We also want to learn more about the side effects the study drug may cause.
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Studying the Long-Term Usefulness of a Parkinson's Disease Treatment
The purpose of this study is to see how well the drug ABBV-951 works for people with advanced Parkinson's Disease over a long time. We will look at how the drug affects movement, daily activities, and changes in the disease over three years. We need volunteers who have never taken the drug before or who have used it before. The study team will give more details.
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Testing a New App for Radiation Skin Rash in Head and Neck Cancer Patients
We want to learn about a new mobile app called MyCap for people with head and neck cancer who are getting radiation therapy. The study will check if the app can collect information about skin rashes caused by radiation. Volunteers will need to use their own mobile device to access the app. You are invited to join this study because you have head and neck cancer and will get radiation therapy.
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Studying Two Treatments for Early Stage Breast Cancer
The purpose of this study is to learn more about adding chemotherapy to hormone treatment for breast cancer. We will compare two common treatments to see which works better. The goal is to find out if adding chemotherapy can prevent the cancer from returning and learn more about the possible side effects. We are looking for volunteers who have early-stage breast cancer, are HER2-negative, and have not gone through menopause yet.
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Studying a New Weight Loss Medicine for Overall Health Among Older Adults
The purpose of this study is to learn more about a weight loss medicine called tirzepatide. We want to see how this medicine affects body fat, bones, and how well older adults can move. Volunteers in the study will take the medicine and join sessions about healthy eating and exercise. The goal is to see if the drug helps improve health in older adults who are overweight or obese.
Study Topics
Men's Health Weight, Metabolism, Nutrition Wellness and Lifestyle Women's Health
Testing the Study Drug SNDX-5613 for Patients with Newly Diagnosed Acute Myeloid Leukemia
The purpose of this study is to learn more about the study drug SNDX-5613. We want to see if adding this study drug to the usual treatment can help patients who have just been diagnosed with a type of blood cancer called acute myeloid leukemia. We want to find out how much of the drug will cause serious side effects in patients. This will help doctors find out the best amount of the drug to use in future treatments for this cancer.
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Testing a New Treatment for Muscle Weakness
The purpose of this study is to test a new treatment called YTB323 for people with generalized myasthenia gravis. We want to see if YTB323 is safe and helps improve muscle strength. Participants will receive the treatment through an IV infusion.
Study Topics
Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders Bones, Joints, Muscles
Comparing Metformin and Insulin for Gestational Diabetes
The purpose of this study is to see if the medicine Metformin works as well and is as safe as insulin for treating diabetes during pregnancy. We also want to know which treatment pregnant people with diabetes like better and how it affects their pregnancy.
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A Study of the Drug Seladelpar for Liver Disease and Scarring of the Liver
The purpose of this study is to learn more about the study drug Seladelpar. We want to see if the study drug can help treat patients with chronic liver disease and scarring of the liver. We will look at changes in overall health, severity of symptoms, and progression of disease.
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Studying the Drug Bomedemstat for Patients with Essential Thrombocythemia
The goal of this study is to learn more about a drug called Bomedemstat. We want to find out if this drug is safe and helpful for people with a rare blood disease called essential thrombocythemia. We also want to see how this drug compares to the best treatments available for this disease.
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Comparing Two Treatments for Breast Cancer after Surgery
The goal of this study is to test a new treatment for a type of breast cancer called high-risk early triple-negative breast cancer. We want to see if using the drugs sacituzumab govitecan and pembrolizumab together can treat cancer that is still there after surgery and keep it from coming back. The researchers will compare this to using pembrolizumab alone or with another drug called capecitabine.
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Women's Health and Future Pregnancies
The goal of this study is to learn how a woman's health, including what she eats and the activities she does, affects her and her baby if she gets pregnant. We are inviting women under 40 who are overweight or obese and might become pregnant to volunteer for this study. The study team will provide more details.
Study Topics
Healthy Volunteers Weight, Metabolism, Nutrition Wellness and Lifestyle Women's Health
Testing a New Rescue Inhaler for Patients with Asthma
The purpose of this study is to see if a new type of inhaler with a different ingredient is safe and works well for patients with asthma. The new inhaler has a substance called HFA-152a, which the FDA hasn't approved yet. We'll compare it to the current inhaler called Ventolin, which has HFA-134a.
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Studying the Drug AOC 1001 for Patients with Myotonic Dystrophy Type 1
The purpose of this study is to learn more about the study drug AOC 1001. We want to see how safe and useful the study drug is for the treatment of myotonic dystrophy type 1.
Study Topics