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Studying a Blood Test to Guide Cancer Treatment After Surgery
The purpose of this study is to see if a blood test can help doctors decide who needs extra cancer treatment after surgery for bladder, kidney. Ureter, or urethra cancer. The blood test looks for cancer DNA in the blood. If the test finds cancer DNA, patients may get one or two cancer drugs, or they may be watched closely.
Study Topics
Cancer Cancer: Kidney, Liver, Pancreas Cancer: Urinary and Bladder
Studying New Glucose Sensors for People with Diabetes
The purpose of this study is to see how well new glucose sensors work. These sensors help people with diabetes track their blood sugar. The study compares the new sensors to ones already sold in stores.
Study Topics
Learning the Best Ways to Treat Broken Bones and Reduce Future Fractures
The purpose of this study is to learn more about different ways to care for patients after they break a bone and to reduce your chances of having another fracture. We are looking for volunteers with a recent bone break and who have a regular doctor. They also must not have certain health conditions like cancer, severe kidney disease, or other bone diseases. The study team will provide more information.
Study Topics
Managing Osteoarthritis Pain with Movement and Healthy Eating at Home
Osteoarthritis is a condition that causes pain and stiffness in the joints, often in the hips and knees. The purpose of this study is to find ways to help people with chronic pain due to this condition. We want to find a drug-free way to better manage symptoms through movement and healthy eating. The study is done entirely at home with virtual visits and assessments. The study team will provide more details.
Study Topics
Pain Arthritis, Lupus, and Autoimmune Disorders Weight, Metabolism, Nutrition Bones, Joints, Muscles
Helping Patients Manage Pain and Medicine After Surgery
The purpose of this research is to learn which of three treatments works best for helping people manage pain and use medicine after surgery. We also want to understand how pain, mood, and medicine use change after surgery. One of the treatments is a type of talk therapy called motivational interviewing, which may help people feel better and use less pain medicine. If you join the study, you will be placed into a group by chance-like flipping a coin. We are looking for volunteers who are scheduled for elective orthopedic surgery at Atrium Health Wake Forest Baptist.
Study Topics
Studying Hair Loss and Family History
The purpose of this study is to learn more about what might cause a kind of hair loss called Frontal Fibrosing Alopecia. We are looking for Black or African American women who have this condition. If you join the study, you will be asked to answer a short survey, have pictures taken of your scalp, and give a saliva sample so we can look at your DNA. We are also looking for family members-whether they have hair loss or not-to take part. This is not a treatment study.
Study Topics
Helping People with HIV Quit Smoking Using Apps
The purpose of this study is to learn more about two different ways to help people with HIV quit smoking. The first way is to use the app called QuitStart along with the use of nicotine gum and patches. The second way is to use the app called Learn to Quit-HIV (LTQ-H) along with the use of nicotine gum and patches. We will compare each way to understand the pros and cons of each approach. We are looking for volunteers who have HIV and have smoked cigarettes every day in the past 30 days.
Study Topics
HIV/AIDS Substance Use (Alcohol, Illegal Drugs, Tobacco) Wellness and Lifestyle
Studying Bone and Kidney Problems in Patients with Diabetes and Nerve Damage in their Feet
The purpose of this study is to learn how your kidneys affect the bones in your feet. We believe that healthy kidneys help keep your foot bones strong. Having diabetes and nerve damage can increase your chances of having kidney and foot problems. You will help us understand more about how they are related which will ultimately help us discover tests and treatments to prevent diabetes related foot problems.
Study Topics
How Muscles Affect Walking as We Get Older
The purpose of this study is to find out why some older adults lose the ability to walk easily. Our researchers will test how changes in muscles, like strength and energy, affect walking and fitness. The goal is to find ways to help people stay active and independent as they age. To learn more, please visit our website here: www.sommastudy.com/somma2
Study Topics
Aging Men's Health Pain Wellness and Lifestyle Women's Health Bones, Joints, Muscles
Using Metformin to Improve Sleep
This study wants to find out if a medicine called metformin can help people sleep better. It looks at how metformin affects a special kind of sleep that helps with learning and memory. The study also checks if metformin can fix daily activity and rest patterns that get messed up by health problems.
Study Topics
Studying a New Medicine for CIDP Nerve Disease
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) is a nerve disease that causes weakness and numbness. The purpose of this study is to learn more about a new medicine called TAK-881 for this disease. Everyone in the study will get TAK-881, and doctors will compare it to another medicine called HYQVIA. The goal is to find out if TAK-881 works better or is easier to use.
Study Topics
Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders
Treating Recurrent Small Cell Lung Cancer with a New Combination of Medications
The purpose of this study is to find a safe dose of the drugs pembrolizumab, tazemetostat and topotecan. We want to see if this combination will lower the chance of relapsed SCLC growing or spreading.
Study Topics
Comparing Two Treatments for People With Low Tumor Burden Follicular Lymphoma
The purpose of this study is to learn more about the drug mosunetuzumab. We want to see if this drug works better than the usual treatment for a type of cancer called low tumor burden follicular lymphoma.
Study Topics
Testing Genes for Cystic Fibrosis Diabetes
The purpose of this study is to understand why people with cystic fibrosis get diabetes. Both diseases are caused by changes in DNA and other molecules in the blood. These changes can cause thick mucus in the pancreas, which damages cells that make insulin, leading to diabetes.
Study Topics
Genetic Disorders Lung Health Children, Infants, Teen Health Diabetes
Learning More About Living with Darier's Disease
Darier's disease is a rare skin condition that causes wart-like bumps. The purpose of this study is to learn more about the daily challenges faced by people with Darier's disease.
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Testing the Study Drug SGN-MesoC2 for Advanced Solid Tumors
The purpose of this study is to learn more about a new study drug called SGN-MesoC2. We want to see if this study drug is safe and helpful for people with advanced solid tumors. We are looking for volunteers with certain types of cancer that have spread or cannot be removed by surgery. These types of cancers include ovarian cancer, lung cancer, pancreatic cancer, endometrial cancer, colorectal cancer, or mesothelioma.
Study Topics
Testing an App for Better Sleep in Blood Cancer Patients
The purpose of this study is to test two wellness apps and see which one helps cancer patients sleep better. We want to find out how these apps affect sleep, immune health, and overall well-being of blood cancer patients during treatment.
Study Topics
Testing Seizure Medicine for Kids
The purpose of this study is to test a liquid medicine called zonisamide for kids with seizures. We want to see how the medicine moves in the body and if it is safe. The study is for kids aged 1 month to 17 years who have partial-onset seizures.
Study Topics
Testing the Use of Daratumumab-Hyaluronidase for Treating T Cell Acute Lymphoblastic Leukemia
The purpose of this study is to test a new care program to help people with psoriasis lower their risk of heart disease. Examples of health risks are high cholesterol, high blood pressure, diabetes, and smoking that can lead to heart attacks or strokes. We want to see if a care coordinator can help patients manage their heart health better.
Study Topics