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Exploring a New Program to Care for Rural Patients with Chronic Pain
The purpose of this study is to test a new program for patients in rural areas with chronic pain. We want to see if this program can help patients better manage their pain and daily functioning by working with a nurse care manager.
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A Study of the Drug Reparixin for Patients with Myelofibrosis
The purpose of this study is to learn more about the study drug Reparixin. This study drug is for people with a type of blood cancer called myelofibrosis. We want to find out if Reparixin is safe and if it helps treat this cancer.
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Testing the Study Drug Levocarnitine to Prevent Liver Damage in Leukemia or Lymphoma Patients
The purpose of this study to learn more about the study drug Levocarnitine. We want to see if this study drug protects the liver from chemotherapy for leukemia or lymphoma.
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Testing the Study Drug Lutikizumab for Severe Skin Disease
Hidradenitis suppurativa is a skin problem that causes painful bumps and boils under the skin. The purpose of this study is to find out if the study drug lutikizumab is safe and useful for treating this skin problem.
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Studying the Medicine Apitegromab for Babies with Muscle Weakness
Spinal muscular atrophy is a disease that makes muscles weak and hard to move. The purpose of this study is to test a new medicine called apitegromab. We want to see if it is safe and helpful for babies under 2 years old who still have trouble moving even though they already got another treatment called survival motor neuron therapy.
Study Topics
Genetic Disorders Movement Disorder Neurology Disorders Rare Disease Bones, Joints, Muscles Children, Infants, Teen Health
Studying a Blood Test to Guide Cancer Treatment After Surgery
The purpose of this study is to see if a blood test can help doctors decide who needs extra cancer treatment after surgery for bladder, kidney. Ureter, or urethra cancer. The blood test looks for cancer DNA in the blood. If the test finds cancer DNA, patients may get one or two cancer drugs, or they may be watched closely.
Study Topics
Cancer Cancer: Kidney, Liver, Pancreas Cancer: Urinary and Bladder
Studying New Glucose Sensors for People with Diabetes
The purpose of this study is to see how well new glucose sensors work. These sensors help people with diabetes track their blood sugar. The study compares the new sensors to ones already sold in stores.
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Learning the Best Ways to Treat Broken Bones and Reduce Future Fractures
The purpose of this study is to learn more about different ways to care for patients after they break a bone and to reduce your chances of having another fracture. We are looking for volunteers with a recent bone break and who have a regular doctor. They also must not have certain health conditions like cancer, severe kidney disease, or other bone diseases. The study team will provide more information.
Study Topics
Managing Osteoarthritis Pain with Movement and Healthy Eating at Home
Osteoarthritis is a condition that causes pain and stiffness in the joints, often in the hips and knees. The purpose of this study is to find ways to help people with chronic pain due to this condition. We want to find a drug-free way to better manage symptoms through movement and healthy eating. The study is done entirely at home with virtual visits and assessments. The study team will provide more details.
Study Topics
Pain Arthritis, Lupus, and Autoimmune Disorders Weight, Metabolism, Nutrition Bones, Joints, Muscles
Comparing Different Migraine Medicines
The purpose of this study is to learn more about two different ways to help people with HIV quit smoking. The first way is to use the app called QuitStart along with the use of nicotine gum and patches. The second way is to use the app called Learn to Quit-HIV (LTQ-H) along with the use of nicotine gum and patches. We will compare each way to understand the pros and cons of each approach. We are looking for volunteers who have HIV and have smoked cigarettes every day in the past 30 days.
Study Topics
HIV/AIDS Substance Use (Alcohol, Illegal Drugs, Tobacco) Wellness and Lifestyle
Comparing Different Migraine Medicines
The purpose of this study is to learn more about three migraine medicines: atogepant, propranolol, and topiramate. Our researchers want to see which one helps prevent migraines the best. Volunteers in the study will try one medicine and keep track of their headaches. The results will help doctors and patients choose the best medicine for migraine prevention.
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Studying Hair Loss and Family History
The purpose of this study is to learn more about what might cause a kind of hair loss called Frontal Fibrosing Alopecia. We are looking for Black or African American women who have this condition. If you join the study, you will be asked to answer a short survey, have pictures taken of your scalp, and give a saliva sample so we can look at your DNA. We are also looking for family members-whether they have hair loss or not-to take part. This is not a treatment study.
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Studying Pump Chemotherapy For Colorectal Cancer that Spread to the Liver
Hepatic arterial infusion (HAI) chemotherapy is a way to give cancer medicine straight into the liver using a small pump. The purpose of this study is to see if using this type of chemotherapy with regular chemotherapy can help people with colorectal cancer that has spread to the liver. Doctors will compare people who get both treatments to people who get only regular chemotherapy. The goal is to find out which treatment helps patients live longer and feel better.
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Studying Aspirin Use During Pregnancy
The purpose of this study is to learn more about aspirin use during pregnancy. We want to see if using more aspirin can help lower the chance of having a baby too early or stillborn. Our researchers will compare two different aspirin doses to see which works better for moms and babies. We are looking for volunteers who are between 10 and almost 16 weeks pregnant and who have had a baby born more than five weeks early in the past.
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Helping Patients Manage Pain and Medicine After Surgery
The purpose of this research is to learn which of three treatments works best for helping people manage pain and use medicine after surgery. We also want to understand how pain, mood, and medicine use change after surgery. One of the treatments is a type of talk therapy called motivational interviewing, which may help people feel better and use less pain medicine. If you join the study, you will be placed into a group by chance-like flipping a coin. We are looking for volunteers who are scheduled for elective orthopedic surgery at Atrium Health Wake Forest Baptist.
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Studying Bone and Kidney Problems in Patients with Diabetes and Nerve Damage in their Feet
The purpose of this study is to find out why some older adults lose the ability to walk easily. Our researchers will test how changes in muscles, like strength and energy, affect walking and fitness. The goal is to find ways to help people stay active and independent as they age. To learn more, please visit our website here: www.sommastudy.com/somma2
Study Topics
Aging Men's Health Pain Wellness and Lifestyle Women's Health Bones, Joints, Muscles
Studying Bone and Kidney Problems in Patients with Diabetes and Nerve Damage in their Feet
The purpose of this study is to learn how your kidneys affect the bones in your feet. We believe that healthy kidneys help keep your foot bones strong. Having diabetes and nerve damage can increase your chances of having kidney and foot problems. You will help us understand more about how they are related which will ultimately help us discover tests and treatments to prevent diabetes related foot problems.
Study Topics
Aging Men's Health Pain Wellness and Lifestyle Women's Health Bones, Joints, Muscles
Study of Two Medicines for Diabetes, Blood Pressure, and Heart Disease
The purpose of this study is to find out if taking two medicines together helps people with type 2 diabetes, high blood pressure, and heart disease. Our researchers will compare the medicines to a look-alike pill with no medicine inside. The goal is to see if the medicines can lower the chance of serious health problems like heart attacks or strokes.
Study Topics
Treating Recurrent Small Cell Lung Cancer with a New Combination of Medications
The purpose of this study is to find a safe dose of the drugs pembrolizumab, tazemetostat and topotecan. We want to see if this combination will lower the chance of relapsed SCLC growing or spreading.
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