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Learning More About the Effects of Very Low-Nicotine Cigarettes on the Heart
The purpose of this study is to learn more about the effects of very low-nicotine cigarettes on the heart.
Study Topics
Heart Health Substance Use (Alcohol, Illegal Drugs, Tobacco)
Study of the Drug GS-8588 in People with HIV-1 Who are Virologically Suppressed on Antiretroviral Therapy
The purpose of this study is to learn more about the effects of very low-nicotine cigarettes on the heart.
Study Topics
Improving Memory by Improving Sleep
Sleep is a critical part of long-term memory storage. Aging can cause issues with sleep and memory. The goal of this study is to see if improving sleep can improve memory. Volunteers will wear a headband during sleep that will record brain activity. This headband will also provide low-level electrical stimulation to increase deep sleep. Deep sleep is a stage of sleep that is important for memory.
Study Topics
Learning More About Treating Large B-cell Lymphoma or Follicular Lymphoma with Additional Treatment
The purpose of this study is to find out if we can lower the chance of your diffuse large B-cell lymphoma growing or spreading by adding treatment to the usual approach. The usual approach is to watch the patient's condition unless symptoms appear or change. We want to know which approach is better.
Study Topics
Combining the Study Drug, REGN5458, with Other Treatments for Multiple Myeloma
The main purpose of this study is to find out if the study drug, REGN5458, can be given safely with other multiple myeloma treatments. We also want to find out what dose of REGN5458 should be used.
Study Topics
Looking Into the Need of Blood Thinners as Treatment for Atrial Fibrillation
Blood thinning drugs are usually used to treat atrial fibrillation. Atrial fibrillation is when the heart has an irregular and often very fast heart rhythm. Blood thinners lower the risk of stroke but also increase the risk of bleeding. It may not be necessary for people who have short or infrequent atrial fibrillation to take blood thinners. The purpose of this study is to find out if it is safe to stop blood-thinning medication during long periods of normal heart rhythm.
Study Topics
Using Dexpramipexole for the Treatment of Severe Eosinophilic Asthma
The purpose of this study is to find out how well the study drug dexpramipexole works for the treatment of severe asthma. We also want to learn more about the safety of the study drug.
Study Topics
Care Program for Adults with Epilepsy Dealing with Anxiety and/or Depression
The purpose of this study is to find out if emotional quality of life can be improved for those with epilepsy and anxiety and/or depression. We want to see if regular calls or visits with a care manager can help with the anxiety and/or depression symptoms.
Study Topics
Learning More About Online Group Yoga to Help With Depression
The purpose of this study is to find out if yoga can be just as helpful as therapy for treating depression. We want to understand why some people may benefit more from one program or the other.
Study Topics
Study of DSP-5336 for Treatment of Leukemia
Acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and acute leukemia are types of cancer of the blood and bone marrow. This study will help us learn more about a new drug, DSP-5336, that is being tested for treatment of AML, ALL and acute leukemia. The purpose of this study is to find out how safe DSP-5336 is at different doses.
Study Topics
Study of Selinexor for Treating High-Grade Glioma in Pediatric Patients
A glioma is a type of cancer that occurs in the brain or spine. Diffuse intrinsic pontine glioma is a type of high-grade glioma. The purpose of this study is to look at how well selinexor works when given to children and young adults with high-grade glioma or diffuse intrinsic pontine glioma. We also want to find the highest dose of selinexor that we can give safely along with radiation therapy.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Children, Infants, Teen Health
Blood Test to Guide Chemotherapy After Colon Cancer Surgery
This study wants to see if a blood test can help doctors decide which chemotherapy is best after colon cancer surgery. The blood test looks for cancer DNA in the blood. The goal is to find out if this new way is better, the same, or worse than the usual treatment.
Study Topics
Testing the Addition of Radiation Therapy to the Usual Treatment for Advanced Stage Non-small Cell Lung Cancer
The purpose of this study is to find out if we can lower the chance of lung cancer growing or spreading by adding radiation therapy. The radiation therapy will be given along with the usual treatment. We want to find out if this approach is better or worse than the usual approach for lung cancer.
Study Topics
Testing a New Treatment Routine for Patients with Pancreatic Cancer
The purpose of this study is to test a new treatment routine for patients with pancreatic cancer. We want to see how well it works to give two different chemotherapy regimens one after the other.
Study Topics
Treating Prostate Cancer with AMG 509
The purpose of this study is to see how well the study drug, AMG 509, treats prostate cancer. We also want to learn about any side effects caused by the study drug.
Study Topics
Comparing Radiation Given Before or After Brain Metastases Surgery
The purpose of this study is to learn more about treating Hodgkin lymphoma with brentuximab vedotin and nivolumab (Bv-NIVO). We want to see if this treatment works better than the usual treatment.
Study Topics
Comparing Radiation Given Before or After Brain Metastases Surgery
The purpose of this study is to find out if giving radiation before surgery can improve the length of time without the cancer in your brain returning or getting worse. We want to see if this approach is better or worse than the usual approach.
Study Topics
Finding Better Ways to Diagnose and Treat Leukemia in Children, Adolescents and Young Adults
The purpose of this study is to test bone marrow and blood from people with leukemia. We want to see if the leukemia has certain traits that could help the doctors decide what medicine might be best for you. This study will also collect information about your treatment for leukemia. We want to see how well it worked and find out if there were any long-term side effects.
Study Topics
Study to Find Out How Well Pritelivir Works for Treating Skin Lesions Caused by Herpes
In patients with an impaired immune system, herpes ulcers are usually extensive, deep and cause severe pain. The standard treatment sometimes doesn't work for these patients. The purpose of this study is to see how well the study drug, Pritelivir, may work for this group of patients. We also want to find out what side effects may be caused by the study drug.
Study Topics