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Using Dexpramipexole for the Treatment of Severe Eosinophilic Asthma
The purpose of this study is to find out how well the study drug dexpramipexole works for the treatment of severe asthma. We also want to learn more about the safety of the study drug.
Study Topics
Care Program for Adults with Epilepsy Dealing with Anxiety and/or Depression
The purpose of this study is to find out if emotional quality of life can be improved for those with epilepsy and anxiety and/or depression. We want to see if regular calls or visits with a care manager can help with the anxiety and/or depression symptoms.
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Learning More About Online Group Yoga to Help With Depression
The purpose of this study is to find out if yoga can be just as helpful as therapy for treating depression. We want to understand why some people may benefit more from one program or the other.
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Study of DSP-5336 for Treatment of Leukemia
Acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and acute leukemia are types of cancer of the blood and bone marrow. This study will help us learn more about a new drug, DSP-5336, that is being tested for treatment of AML, ALL and acute leukemia. The purpose of this study is to find out how safe DSP-5336 is at different doses.
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Study of Selinexor for Treating High-Grade Glioma in Pediatric Patients
A glioma is a type of cancer that occurs in the brain or spine. Diffuse intrinsic pontine glioma is a type of high-grade glioma. The purpose of this study is to look at how well selinexor works when given to children and young adults with high-grade glioma or diffuse intrinsic pontine glioma. We also want to find the highest dose of selinexor that we can give safely along with radiation therapy.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Children, Infants, Teen Health
Using Cancer Cells in the Blood to Determine the Type of Chemotherapy that Will Benefit Colon Cancer Patients After Surgery
The purpose of this study is to help us learn more about using circulating tumor DNA (ctDNA) results to decide what chemo to offer patients after colon cancer surgery. ctDNA is DNA that has been released from tumor cells into your blood. Finding ctDNA in your blood means that there are likely small amounts of cancer after surgery. This study will help us find out if using ctDNA results to decide on treatment is better than the usual approach.
Study Topics
Testing the Addition of Radiation Therapy to the Usual Treatment for Advanced Stage Non-small Cell Lung Cancer
The purpose of this study is to find out if we can lower the chance of lung cancer growing or spreading by adding radiation therapy. The radiation therapy will be given along with the usual treatment. We want to find out if this approach is better or worse than the usual approach for lung cancer.
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Studying Causes of Heart Failure
This purpose of this study is to understand what causes heart failure. Some people with early-stage heart failure might not know they have it because they feel fine, while others may have many or few symptoms. We want to learn why some people get heart failure and how to better classify it for targeted treatments. We are recruiting volunteers with and without heart failure to learn more.
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Testing a New Treatment Routine for Patients with Pancreatic Cancer
The purpose of this study is to test a new treatment routine for patients with pancreatic cancer. We want to see how well it works to give two different chemotherapy regimens one after the other.
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Treating Prostate Cancer with AMG 509
The purpose of this study is to see how well the study drug, AMG 509, treats prostate cancer. We also want to learn about any side effects caused by the study drug.
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Learning More About Treating Hodgkin Lymphoma with Brentuximab Vedotin and Nivolumab
The purpose of this study is to learn more about treating Hodgkin lymphoma with brentuximab vedotin and nivolumab (Bv-NIVO). We want to see if this treatment works better than the usual treatment.
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Comparing Radiation Given Before or After Brain Metastases Surgery
The purpose of this study is to find out if giving radiation before surgery can improve the length of time without the cancer in your brain returning or getting worse. We want to see if this approach is better or worse than the usual approach.
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Finding Better Ways to Diagnose and Treat Leukemia in Children, Adolescents and Young Adults
The purpose of this study is to test bone marrow and blood from people with leukemia. We want to see if the leukemia has certain traits that could help the doctors decide what medicine might be best for you. This study will also collect information about your treatment for leukemia. We want to see how well it worked and find out if there were any long-term side effects.
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Treatment for Migraine and Mood
Many people with migraine have challenges related to mood. The purpose of this study is to test three different treatments for improving both migraine and mood.
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Study to Find Out How Well Pritelivir Works for Treating Skin Lesions Caused by Herpes
In patients with an impaired immune system, herpes ulcers are usually extensive, deep and cause severe pain. The standard treatment sometimes doesn't work for these patients. The purpose of this study is to see how well the study drug, Pritelivir, may work for this group of patients. We also want to find out what side effects may be caused by the study drug.
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Learning More About How Patients Take Their Psoriasis Medication
The purpose of this study is to learn more about how people choose to take their psoriasis medication. We want to find out if sending daily and weekly reminders will help patients take their medication as directed. The study will also look at how well the medication works for patients who take it as directed compared to those who do not. Taking part in this study involves two office visits, taking a daily med, and an exit interview.
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Treating Glioblastoma with the Study Drug Dichloroacetate
The purpose of the study is to find out if the study drug, Dichloroacetate, can keep glioblastomas from growing. We want to know if the study drug can help improve the health of patients with glioblastomas that have returned or been difficult to treat.
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Learning More About Treating Childhood Absence Epilepsy and Juvenile Absence Epilepsy with Brivaracetam
The purpose of this study is to see how well the study drug, brivaracetam, treats childhood absence epilepsy or juvenile absence epilepsy. We also want to learn more about any possible side effects it may cause.
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Learning More About Preventing Bone Loss in Older Adults that Have Lost Weight
The purpose of this study is to see if losing weight affects bone health in older adults. You will join a group to help you lose weight and may do exercises at a gym three times a week. You might also take a pill called alendronate, which helps keep bones strong, or a placebo for one year.
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Reducing Distress and Tobacco Use in Cancer Survivors with At-Home Brain Stimulation
The purpose of this study is to find out if transcranial direct current stimulation (TDCS) is easy to use at home. We also want to find out how well it works for reducing distress and decreasing cigarette use. TDCS is a form of brain stimulation. This type of stimulation is done outside of the body. The largest risk with this study is minor discomfort such as warmth, itching or tingling sensation during treatment.
Study Topics
Mental Health Substance Use (Alcohol, Illegal Drugs, Tobacco) Cancer