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Comparing Hearing Loss in Cancer Patients
The main goal of this study is to find out if there is a difference in hearing loss between cancer patients who get the treatment cisplatin and those who get the treatment carboplatin. We want to know how hearing loss affects patients in their daily lives. To find out, we will make a questionnaire that asks about your own experiences with hearing loss or hearing problems. We are looking for volunteers with germ cell tumors who have been treated with either cisplatin or carboplatin.
Study Topics
Cancer Cancer: Children, Teens Cancer: Rare Cancers Cancer: Solid Tumor
Comparing a New Treatment For Blood Cancer Patients
The purpose of this study is to learn about a new treatment called Inotuzumab Ozogamicin. We want to see if it helps people with blood cancer. We will compare the results of patients who get this new treatment with those who get the usual treatment. We are looking for volunteers who are newly diagnosed with one of these blood cancers: high-risk B-cell acute lymphoblastic leukemia (B-ALL), mixed-phenotype acute leukemia (MPAL), or disseminated B lymphoblastic lymphoma (B-LLy).
Study Topics
Cancer Cancer: Blood Cancer: Children, Teens Cancer: Leukemia
Comparing Chemotherapy Schedules for Germ Cell Tumors
The purpose of this study is to find out if giving chemotherapy drugs on a faster schedule helps patients with advanced germ cell tumors. We will compare the regular 3-week cycle with a faster paced 2-week cycle. We want to see if the faster schedule is useful and safe for the patients.
Study Topics
Learning More about a New AML Cancer Treatment
The purpose of this study is to learn more about a cancer medicine called venetoclax. We want to see if adding this medicine to the usual chemotherapy can help treat patients with newly diagnosed myeloid leukemia (AML). We will compare this new treatment to the usual treatment for this type of cancer.
Study Topics
Improving Cancer Care for Young Patients
The purpose of this study to find better ways to diagnose, treat, and prevent cancers in children, teenagers, and young adults. Our goal is to gather information about cancer treatments and their results to improve future care. We are looking for volunteers who have cancer or other conditions where cells grow abnormally. The study team will provide more details.
Study Topics
A Study of the Drug Reparixin for Patients with Myelofibrosis
The purpose of this study is to learn more about the study drug Reparixin. This study drug is for people with a type of blood cancer called myelofibrosis. We want to find out if Reparixin is safe and if it helps treat this cancer.
Study Topics
Testing the Study Drug Levocarnitine to Prevent Liver Damage in Leukemia or Lymphoma Patients
The purpose of this study to learn more about the study drug Levocarnitine. We want to see if this study drug protects the liver from chemotherapy for leukemia or lymphoma.
Study Topics
Testing the Study Drug DFP-10917 for Patients with Acute Myeloid Leukemia
The purpose of this study is to find out more about the drug DFP-10917. We want to see if it is safe and helpful for treating people with acute myeloid leukemia.
Study Topics
Using the TheraBionic Device to Treat Advanced Pancreatic Cancer
The purpose of this study is to find out how the TheraBionic device will affect pancreatic cancer. The TheraBionic device is a small portable device. We want to see if the device will prevent cancer growth.
Study Topics
Treating Recurrent Small Cell Lung Cancer with a New Combination of Medications
The purpose of this study is to find a safe dose of the drugs pembrolizumab, tazemetostat and topotecan. We want to see if this combination will lower the chance of relapsed SCLC growing or spreading.
Study Topics
Comparing Two Treatments for People With Low Tumor Burden Follicular Lymphoma
The purpose of this study is to learn more about the drug mosunetuzumab. We want to see if this drug works better than the usual treatment for a type of cancer called low tumor burden follicular lymphoma.
Study Topics
Testing the Study Drug SGN-MesoC2 for Advanced Solid Tumors
The purpose of this study is to learn more about a new study drug called SGN-MesoC2. We want to see if this study drug is safe and helpful for people with advanced solid tumors. We are looking for volunteers with certain types of cancer that have spread or cannot be removed by surgery. These types of cancers include ovarian cancer, lung cancer, pancreatic cancer, endometrial cancer, colorectal cancer, or mesothelioma.
Study Topics
Testing an App for Better Sleep in Cancer Patients
The purpose of this study is to test two wellness apps and see which one helps cancer patients sleep better. We want to find out how these apps affect sleep, immune health, and overall well-being of blood cancer patients during treatment.
Study Topics
Comparing Two Drugs for Patients with Nodular Lymphocyte-predominant Hodgkin Lymphoma
The goal of this study is to test two different drugs for people with Nodular lymphocyte-predominant Hodgkin lymphoma. We want to see if the drug mosunetuzumab works better than the drug rituximab. We also want to see which drug helps people live longer without their disease getting worse. We are doing this study to find out if this new treatment is better or worse than the usual treatment for this type of lymphoma.
Study Topics
Testing the Use of Daratumumab-Hyaluronidase for Treating T Cell Acute Lymphoblastic Leukemia
Sometimes after a patient with T cell acute lymphoblastic leukemia (T-ALL) has been treated with chemotherapy the leukemia remains at a very low level. This low level of leukemia is called minimal residual disease (MRD). People with MRD have a higher risk for leukemia coming back again. The purpose of this study is to find out if daratumumab and hyaluronidase can get rid of the MRD.
Study Topics
Study the Drug SNDX-5613 for Patients with Leukemia
The purpose of this study is to learn more about a drug called SNDX-5613. We want to see if this drug is safe and helpful when used with chemotherapy for people with a type of blood cancer called acute myeloid leukemia. We are looking for volunteers who are newly diagnosed and have not been treated before.
Study Topics
Testing New Treatments for Large B-Cell Lymphoma
The purpose of this study is to test a new mix of three drugs called lenalidomide, mosunetuzumab, and polatuzumab vedotin. We want to see if these drugs are safe and helpful for people with a type of blood cancer called diffuse large B-cell lymphoma. This study is for patients whose cancer has come back or did not get better with other treatments. We also want to find the highest dose that is still safe for patients.
Study Topics
Testing the anti-cancer drug erdafitinib for brain cancers
The purpose of this study is to test the good and bad effects of the study drug, erdafitinib. We want to find out if the study drug is better or worse than other treatments for brain cancer.
Study Topics
Learning More About the Treatment of Bleeding, Clotting or Non-neoplastic Blood Disorder
The main purpose of this study is to look at the how well the treatments for non-neoplastic blood disorders work. We also want to look at the side effects that may be caused by the treatments.
Study Topics