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Treating Prostate Cancer with AMG 509
The purpose of this study is to see how well the study drug, AMG 509, treats prostate cancer. We also want to learn about any side effects caused by the study drug.
Study Topics
Using Selumetinib for Treating Neurofibromatosis Type 1 and Low-Grade Glioma
The purpose of this study is to see how well a drug called selumetinib works for treating patients with neurofibromatosis type 1 associated low-grade glioma. Low-grade glioma is a type of cancer that affects the nervous system. We also want to see how well selumetinib works at improving vision in patients with low-grade glioma of the optic pathway. The optic pathway includes parts of the eye and brain that help us see.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Children, Teens
Learning More About Treating Hodgkin Lymphoma with Brentuximab Vedotin and Nivolumab
The purpose of this study is to learn more about treating Hodgkin lymphoma with brentuximab vedotin and nivolumab (Bv-NIVO). We want to see if this treatment works better than the usual treatment.
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Testing the Use of Chemo Before and After Pancreatic Cancer Surgery
We would like to find out if chemo before and after pancreatic cancer surgery will help keep the cancer away.
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Comparing Radiation Given Before or After Brain Metastases Surgery
The purpose of this study is to find out if giving radiation before surgery can improve the length of time without the cancer in your brain returning or getting worse. We want to see if this approach is better or worse than the usual approach.
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Using Ultrasound to Detect Neuropathy Caused by Chemotherapy with Oxaliplatin
The purpose of this study is to find out if ultrasound can be used to diagnose damage to nerves caused by the drug Oxaliplatin. Taking part in this study requires one visit. The visit will include ultrasound of the nerve, nerve conduction test, skin biopsy, and examination of your nerves.
Study Topics
Can Genes Predict Your Risk of Lung Cancer
The purpose of this study is to find out if a test of your genes can help determine your risk of lung cancer. The test will use a blood sample and/or cells from your nose collected by a brush.
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Learning More About the Benefits of Chemotherapy Before and After Surgery for Gallbladder Cancer
The usual treatment for gallbladder cancer includes chemotherapy after surgery. We want to find out if it is better to give chemotherapy both before and after surgery. We want to see if this approach is better or worse than the usual approach.
Study Topics
Treating Low-grade Serous Ovarian or Peritoneal Cancer with Letrozole
The purpose of this study is to find out if we can we lower the chance of your ovarian or peritoneal cancer growing or spreading with the study drug Letrozole. We want to find out if this approach is better or worse than the usual approach for treating this type of cancer.
Study Topics
Cancer Cancer: Rare Cancers Cancer: Sarcoma (Bone, Muscle, Soft Tissue) Cancer: Women's Cancer
Comparing Two Surgical Procedures to Reduce the Risk of Ovarian Cancer
The purpose of this study is to compare two different surgeries to reduce the risk of ovarian cancer. The study will look at the process used to decide which surgery is best for the patient. It will also look at symptoms that occur after removal of the ovaries.
Study Topics
Treating Head and Neck Cancer with Tisotumab Vedotin
The purpose of this study is to find out how well the study drug, Tisotumab Vedotin, works for treating solid tumor cancer. We also want to learn more about any side effects the study drug may have.
Study Topics
Comparing Stereotactic Radiosurgery to Whole Brain Radiotherapy
The purpose of this study is to find out if stereotactic radiosurgery can reduce your symptoms and lower the chance of the cancer growing or getting worse. Stereotactic radiosurgery is commonly used to treat brain tumors. It is a one or two-day outpatient procedure. A high dose of radiation is delivered to small spots in the brain not including the normal brain. We want to find out if this approach is better or worse than the usual approach for cancer that has spread to the brain.
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Study of the Drug Blinatumomab in Patients with Acute Lymphoblastic Leukemia
Blinatumomab is a drug approved by the US Food and Drug Administration to treat B-precursor acute lymphoblastic leukemia. Blinatumomab is given by daily infusion for 28 days per cycle. The first few infusions of Cycles 1 and 2 are given in the hospital. The purpose of this study is to see if Blinatumomab can be given at home safely for the entire 28-day cycle.
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A Study of the Drug ABBV-383 for Patients with Multiple Myeloma
The purpose of this study is to learn more about the study drug ABBV-383 for patients with multiple myeloma that has returned or has not responded to treatment. We want to find the best dose and learn about the safety and effects of the study drug.
Study Topics
Can Immunotherapy Help Non-Small Cell Lung Cancer Patients Improve Physical Function
The purpose of this study is to see if treatment with immunotherapy can help lung cancer patients who get tired easily and struggle with some daily tasks.
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Using Modified Immune Cells to Treat Peripheral T Cell Lymphoma
Peripheral T cell lymphoma is a type of cancer of the immune system. This study involves using your own modified immune cells as an experimental treatment. The purpose of this study is to find out if this treatment is safe. We also want to learn more about the possible side effects of this treatment.
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Finding Better Ways to Diagnose, Treat and Prevent Cancer in Children
The purpose of creating the database is to help find better ways to diagnose, treat and prevent cancer in children.
Study Topics
Is it More Helpful to Give Children with Germ Cell Tumors Chemotherapy on a Faster Schedule
A germ cell tumor is a type of cancer found in the ovaries for females or the testes for males. This tumor may also be found in the pelvis along the tailbone, chest, abdomen, and other structures of the body. Chemotherapy is the medicine used to fight cancer. We want to find out if giving children with germ cell tumors chemotherapy on a faster schedule is effective.
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A study on the Effectiveness of Four Drugs (Vismodegib, GSK2256098, capivasertib, abemaciclib) Against Meningioma Tumors
The purpose of this study is to see if tumor genetic testing would be helpful when selecting a treatment for meningioma. The usual treatment for meningioma is the same for all patients and not based on tumor genetic testing. This study will look at the tissue of your tumor to see what types of mutations it has across different types of genes. Study treatment will be based on the type of altered genes in your tumor.
Study Topics
A Study of the Drug ABBV-383 for Patients with AL Amyloidosis
The purpose of this study is to learn more about the study drug ABBV-383 in patients with amyloidosis. We want to find the best dose and learn about the safety and effects of the study drug.
Study Topics