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Testing a New Heart Device for Patients with Heart Failure
The purpose of this study is to learn more about a study device called the OPTIMIZER Smart for patients with heart failure. We want to gather information on this device and see if it helps improve heart function and quality of life.
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Treating Relapsing Multiple Sclerosis with BIIB091
The purpose of this study is to find out how well a new drug called BIIB091 works for treating relapsing multiple sclerosis. We also want to find out how well the body can handle taking the study drug.
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Looking at How Estrogen Deprivation Affects Heart Function in Breast Cancer Patients
The purpose of this study is to learn more about how near complete estrogen deprivation therapy effects the heart in breast cancer patients. We want to understand if this therapy changes how the heart works.
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Testing a Study Device for Pulmonary Regurgitation
The purpose of this study is to test a study device called Medtronic Harmony Transcatheter Pulmonary Valve for the treatment of this condition. We want to learn more about the safety and effectiveness of this device.
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Using Anifrolumab to Treat Lupus Nephritis
The purpose of this study is to learn more about a new lupus nephritis treatment called Anifrolumab. We want to find out how well it works and what side effects it may have.
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New Tool to Measure Progression of Parkinson's Disease
Eye movement tasks have long been used as a measure of sensory, motor, and cognitive function. These tasks can possibly be used as a way to measure the progression of diseases like Parkinson's. The purpose of this study is to create a new tool to measure the progression of Parkinson's disease. Having such a tool could lead to better diagnosis and treatment in the future.
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A Study of the Drug Staccato Alprazolam for Patients with Prolonged Seizures
The purpose of this study is to learn more about the study drug Staccato Alprazolam. We want to see how well the study drug works for treating patients with previous episodes of prolonged seizures. We also want to learn more about the safety and side effects that may be caused by the study drug.
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Adding Tazemetostat to the Usual Treatment for Melanoma
The purpose of this study is to find out if the study drug, tazemetostat, can keep your melanoma from getting worse. We also want to see if the study drug alone is better or worse than adding the study drug to the usual treatment.
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Can Regular Phone Calls with a Care Manager Improve Quality of Life for People with Post-Traumatic Epilepsy
The purpose of this study is to find out if regular phone calls from a care manager can help patients with post-traumatic epilepsy and symptoms of anxiety and/or depression. The care manager will talk about anxiety, depression, seizures and side effects. They will also provide you with brief therapy sessions. We want to know if this approach helps improve emotional quality of life.
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Testing a Device to Prevent Stroke in Patients with Patent Foramen Ovale
The purpose of this study is to test a new study device called the GORE CARDIOFORM Septal Occluder. We want to see if this device can help patients with this heart condition by closing the hole in the heart and preventing another stroke.
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Treating Recurrent Grade IV Glioma with NEO100
The purpose of this study is to find out how well the study drug, NEO100, works for treating glioblastoma that has returned after treatment.
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Finding Out How Well Rimegepant Works for Treating Migraines in People Ages 12 to 17
The purpose of this study is to find out how well the study drug, Rimegepant, works for treating migraines in people age 12 to 17. We also want to find out how safe it is in children and young people.
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Neurology Disorders Pain Brain and Memory Children, Infants, Teen Health
Collecting Data on Patients with Cystic Fibrosis
The purpose of this study is to gather information on people with cystic fibrosis through a patient registry. The patient registry helps track important changes in people with cystic fibrosis. It also helps doctors understand the disease better, improve treatments, and help patients live longer.
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Genetic Disorders Lung Health Children, Infants, Teen Health
Learning More About Treating of Acute Graft Versus Host Disease with Itolizumab
The purpose of this study is to see how well the study drug, Itolizumab, works for treating acute graft vs host disease. We also want to learn more about side effects the study drug may cause.
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Learning More About Treating Glioma with the Study Drug OKN-007
The purpose of this study is to find out how well the study drug, OKN-007, works for treating glioma. We also want to determine what dose is safe and well tolerated.
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Learning More About the Long-Term Use of the Study Drug Staccato Alprazolam for Prolonged Seizures
The purpose of this study is to learn more about the long-term use of the study drug Staccato Alprazolam. We want to see how well the study drug works when used long-term for patients with a history of prolonged seizures. We also want to learn more about the safety and side effects that may be caused by the study drug.
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Using Muscle Fiber Fragment Injections to Treat Fecal Incontinence
The purpose of this study is to look at a new way to treat fecal incontinence. We want to know if injecting muscle fiber fragments into the muscle at the bottom of the anus can help with leaking stool.
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Learning More About Treating Large B-cell Lymphoma or Follicular Lymphoma with Additional Treatment
The purpose of this study is to find out if we can lower the chance of your diffuse large B-cell lymphoma growing or spreading by adding treatment to the usual approach. The usual approach is to watch the patient's condition unless symptoms appear or change. We want to know which approach is better.
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Comparing Ways to Improve Blood Flow in Newborns' Lungs
The purpose of this study is to looks at two different methods to help increase blood flow in the lungs of newborn babies. One method uses a shunt, which is a small tube, and the other uses a stent, which is a tiny mesh-like device. We want to learn if one of the two options is better than the other.
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Combining the Study Drug, REGN5458, with Other Treatments for Multiple Myeloma
The main purpose of this study is to find out if the study drug, REGN5458, can be given safely with other multiple myeloma treatments. We also want to find out what dose of REGN5458 should be used.
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