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A study on the effectiveness of the drug SAR442168 in Participants With Primary Progressive Multiple Sclerosis
The purpose of the study is to see if the study drug, SAR442168, works to delay the progression of disability in people with primary progressive multiple sclerosis (PPMS) compared to placebo (a substance that has no effect). PPMS is one type of Multiple Sclerosis, which is a group of disease that over time, affect your brain's ability to control your body.
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Testing a Study Device for Chronic Venous Insufficiency
Chronic venous insufficiency happens when blood gets stuck in the veins of the legs because the valves do not work right. This study wants to see if the study device Venclose™ digiRF™ Generator and its catheters are safe and good at treating this problem. We want to know if these devices can help fix the veins in the legs and stop them from leaking. The study will also check if the devices are safe to use.
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Learning More About How Radiation Therapy May Affect Carotid Arteries
The purpose of this study is to understand how radiation therapy may affect blood vessels in your neck called the carotid arteries. We want to look at narrowing of the artery or thickening of the walls of the arteries.
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Learning More About Treating Childhood Absence Epilepsy and Juvenile Absence Epilepsy with Brivaracetam
The purpose of this study is to see how well the study drug, brivaracetam, treats childhood absence epilepsy or juvenile absence epilepsy. We also want to learn more about any possible side effects it may cause.
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A Study of the Drug Batoclimab for Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disorder. The purpose of this study is to learn more about the study drug Batoclimab. We want to see if this study drug is safe and helps people with CIDP.
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Study of Bempedoic Acid for Treating High Cholesterol in Children
Heterozygous familial hypercholesterolemia (HeFH) is an inherited genetic disorder. It causes dangerously high cholesterol levels. This study will see if bempedoic acid works at lowering cholesterol in kids with HeFH. Bempedoic has been tested in adults, but it has not been tested in children or young adults yet.
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Learning More About Preventing Bone Loss in Older Adults that Have Lost Weight
Bone loss can occur in older adults when they lose weight. The purpose of this study is to find ways to minimize that bone loss. Some study volunteers will take weekly alendronate for 52 weeks. Alendronate is a medication that prevents bone breakdown. It has been approved by the US Food and Drug Administration for the prevention and treatment of osteoporosis in older men and women.
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Testing Cardiac Rehab for Amyloidosis
The study aims to find out if exercise programs can help people with this condition feel better.
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Care Program for Adults with Epilepsy Dealing with Anxiety and/or Depression
The purpose of this study is to find out if emotional quality of life can be improved for those with epilepsy and anxiety and/or depression. We want to see if regular calls or visits with a care manager can help with the anxiety and/or depression symptoms.
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Reducing Distress and Tobacco Use in Cancer Survivors with At-Home Brain Stimulation
The purpose of this study is to find out if transcranial direct current stimulation (TDCS) is easy to use at home. We also want to find out how well it works for reducing distress and decreasing cigarette use. TDCS is a form of brain stimulation. This type of stimulation is done outside of the body. The largest risk with this study is minor discomfort such as warmth, itching or tingling sensation during treatment.
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Mental Health Substance Use (Alcohol, Illegal Drugs, Tobacco) Cancer
A Study of the Drug Deucravacitinib for Patients with Lupus
The purpose of this study is to learn more about the study drug Deucravacitinib. We want to see how well the study drug works for treating Lupus. We also want to learn more about the side effects that may be caused by the study drug.
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Learning More About Online Group Yoga to Help With Depression
The purpose of this study is to find out if yoga can be just as helpful as therapy for treating depression. We want to understand why some people may benefit more from one program or the other.
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Treating Newly Diagnosed Higher-Risk Myelodysplastic Syndrome with Tamibarotene
The purpose of this study is to see how well the study drug, Tamibarotene, works for treating higher-risk myelodysplastic syndrome. The study drug will be given along with a drug called Vidaza. We want to know if this approach is better than the usual approach.
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Finding out if Antiviral Medicine Worked for Babies or Toddlers with Cytomegalovirus Infection
The purpose of this study is to learn more about the treatment with antiviral medicine for babies born with cytomegalovirus. We want to see if antiviral medicine has any impact on hearing, cancer risk, overall growth, or sexual development.
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Infectious Diseases Children, Infants, Teen Health Ears, Nose, Throat, Mouth
Learning More About Adding TRC102 to the Usual Non-Small Cell Lung Cancer Treatment
The purpose of this study is to learn more about the study drug, TRC102. We want to see how it can affect Stage III lung cancer. TRC102 will be added to the usual treatment. The addition of TRC102 to the usual treatment could stabilize your cancer and lengthen the time you can live. This study will help the us find out if this approach is better than the usual approach.
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Health Forum for African-American Men
The purpose of this study is to give African-American men information on health issues. We will also provide tips to improve the overall health and wellness of African-American men.
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Comparing MitraClip and Surgery for Mitral Valve Repair
The purpose of this study is to test a study device called the MitraClipTM Device for patients with this condition and who are at moderate risk of surgery.
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Adding Naxitamab to the Usual Treatment for Neuroblastoma
The purpose of this study is to find out how well Naxitamab works for treating neuroblastoma. Naxitamab will be given along with the usual treatment.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers
Treating Head and Neck Cancer with Cetuximab
The purpose of this study is to see how well the drug Cetuximab works for treating head/neck cancer that stopped responding to treatment. It is possible that Cetuximab may work better when given in patients who have already had immunotherapy.
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Using the GORE® Device to Treat Heart Lesions
Aortic disease may cause wounds in the blood vessels near the heart. We want to learn more about the safety and how well the study device, GORE® Ascending Stent Graft, treats these wounds.
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