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Studying the Drug Bomedemstat for Patients with Essential Thrombocythemia
The goal of this study is to learn more about a drug called Bomedemstat. We want to find out if this drug is safe and helpful for people with a rare blood disease called essential thrombocythemia. We also want to see how this drug compares to the best treatments available for this disease.
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Testing a New Heart Device for Stroke Prevention
The purpose of this study is to test a new heart device called the Laminar System. We want to see if this device is safe and works well for people with a heart condition called non-valvular atrial fibrillation. The study will help doctors understand if this device can prevent strokes in these patients.
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Comparing Two Treatments for Breast Cancer after Surgery
The goal of this study is to test a new treatment for a type of breast cancer called high-risk early triple-negative breast cancer. We want to see if using the drugs sacituzumab govitecan and pembrolizumab together can treat cancer that is still there after surgery and keep it from coming back. The researchers will compare this to using pembrolizumab alone or with another drug called capecitabine.
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Testing a New Heart Valve for Mitral Regurgitation
The purpose of this study is to test a new device called the AltaValve System. We want to see if it can help treat leaky heart valves. We want to find out if the device is safe and works well for people who cannot have open-heart surgery. The study is for adults with mitral valve regurgitation.
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Women's Health and Future Pregnancies
The goal of this study is to learn how a woman's health, including what she eats and the activities she does, affects her and her baby if she gets pregnant. We are inviting women under 40 who are overweight or obese and might become pregnant to volunteer for this study. The study team will provide more details.
Study Topics
Healthy Volunteers Weight, Metabolism, Nutrition Wellness and Lifestyle Women's Health
Comparing Bone Marrow Cancer Treatment Combinations
The purpose of this study is to find out which treatment works best for people who have just been diagnosed with multiple myeloma and cannot have a stem cell transplant. The study compares different combinations of medicines to see which helps people the most. Researchers hope this will help improve care for people with this type of cancer.
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Studying the Drug AOC 1001 for Patients with Myotonic Dystrophy Type 1
The purpose of this study is to learn more about the study drug AOC 1001. We want to see how safe and useful the study drug is for the treatment of myotonic dystrophy type 1.
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Studying a New Treatment Combination for Mantle Cell Lymphoma
The purpose of this study is to learn more about a new medicine combination to help patients with a type of blood cancer called mantle cell lymphoma. We want to see if a new medicine called sonrotoclax combined with the medicine zanubrutinib works better than zanubrutinib alone. Volunteers in the study will be randomly assigned to get either the new medicine or a placebo along with zanubrutinib.
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Studying Risk Factors for Type 2 Diabetes in Youth
Type 2 diabetes is a health problem where the body has too much sugar in the blood. This study wants to find out what makes young people more likely to get this condition early. The information we learn will help us create future studies on how to stop and treat type 2 diabetes in young people.
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Studying a New Treatment for Kids and Teens with Leukemia
The purpose of this study is learn more about a new treatment for children, teens, and young adults with leukemia. The treatment uses regular cancer medicine plus special medicines called dasatinib or imatinib and blinatumomab. The goal is to see if this new combination works better and has fewer side effects than the usual treatment.
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Studying New Treatments for Advanced Breast Cancer
The purpose of this study is to learn more about a new drug, MK-2870, alone or with another drug called pembrolizumab. We want to see how well they work compared to standard chemotherapy. The goal is to find out which treatment helps people live longer and feel better. This study is for volunteers with advanced breast cancer that cannot be removed by surgery.
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Testing the Study Drug Navtemadlin for Patients with Myelofibrosis
This study aims to find out more about using the drug navtemadlin with ruxolitinib. We want to see if these drugs together are safe and helpful for treating myelofibrosis. We also want to know if navtemadlin can help patients who don't improve with just ruxolitinib.
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Testing the Study Drug Pelacarsen to Slow Calcium Build-Up in the Heart Valve
The purpose of this study to learn more about the study drug pelacarsen for patients with calcific aortic valve stenosis. We want to see if the study drug can help safely slow the progression of calcium build-up on the heart valve. Calcium build-up causes narrowing and restricting of blood flow from the heart to the rest of the body.
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Studying a New Medicine for Women's Reproductive Cancers
The goal of this study is to learn more about a new medicine called IMGN151. We want to see if it is safe and if it helps treat cancers that start in parts of a woman's body like the ovaries, uterus, cervix, or vagina. Doctors also want to know if the medicine can help slow down or shrink the cancer.
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Studying a New Medicine for Chronic Graft-Versus-Host Disease
Chronic graft-versus-host disease (cGVHD) is a condition where the donor's cells from a stem cell transplant attack the patient's body, thinking it is not their own. The purpose of this study is to learn more about a new medicine called vimseltinib to see if it is safe and helps people with this condition. The medicine may help by calming down the immune system. Researchers want to find the best dose with the fewest side effects.
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Allergies and Immunity Skin, Hair, Nails Bones, Joints, Muscles
Studying the Medicine Levosimendan for Heart and Lung Health
Pulmonary hypertension with heart failure with preserved ejection is a type of heart failure where the heart does not relax and fill with blood properly. This causes high pressure in the blood vessels in your lungs and makes it harder to breathe. The purpose of this study is to learn more about the medicine levosimendan for people with this condition. We want to see if this medicine can help people walk farther by improving heart and lung function.
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Studying a New Medicine for B-cell Non-Hodgkin Lymphoma
The purpose of this study is to learn more about a new medicine called AZD0486. This medicine is for people with a type of cancer called B-cell non-Hodgkin lymphoma that has come back or did not get better with other treatments. The goal is to see if this medicine is safe and if it helps shrink or stop the cancer.
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Studying the Drug CB-011 for Treatment of Multiple Myeloma
The purpose of this study is to learn more about the study drug CB-01. We want to see if it is safe and helpful for treating people with a type of blood cancer called multiple myeloma that has come back or did not respond to other treatments. This drug uses special cells from a healthy donor to find and kill cancer cells.
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A Study of the Drug ABBV-383 for Treatment of Multiple Myeloma
Multiple myeloma is a type of blood cancer. The purpose of this study is to find out if the study drug ABBV-383 can be safely used with other treatments for this type of cancer. We want to find out the safest dose of the study drug when combined with these treatments. We also want to see if these combinations help patients whose cancer has returned or didn't respond to previous treatments.
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Studying the Medicine BLEXIMENIB for Patients with Acute Myeloid Leukemia
The purpose of this study is to learn more about a new medicine called BLEXIMENIB. We want to see if it works better when added to two other medicines for people with a kind of blood cancer called acute myeloid leukemia (AML). This study is for people with changes in the KMT2A or NPM1 gene, who are not able to get stronger chemotherapy.
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