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Collecting Data on Patients with Cystic Fibrosis
The purpose of this study is to gather information on people with cystic fibrosis through a patient registry. The patient registry helps track important changes in people with cystic fibrosis. It also helps doctors understand the disease better, improve treatments, and help patients live longer.
Study Topics
Genetic Disorders Lung Health Children, Infants, Teen Health
Testing a New Study Device for Patients with Heart Failure
The purpose of this study is to test a new study device called the CCM-D System. We want to see if this device is safe and effective for patients with heart failure and a heart that is not pumping out as much blood as it should with each beat.
Study Topics
Comparing Different Medication Combinations for Brain Artery Narrowing
The purpose of this study is to see how well the combination of study drugs, ticagrelor and aspirin or rivaroxaban and aspirin, help people who have had a stroke from narrowed brain artery. We want to see if the study drugs are better than the usual treatment in preventing another stroke or death.
Study Topics
Collecting Data on Patients with Generalized Myasthenia Gravis
General Myasthenia Gravis is a rare disease that makes it hard for nerves and muscles to work together. This study collects information about people with this disease in a patient registry. The registry helps scientists learn new things that might help others in the future.
Study Topics
Neurology Disorders Rare Disease Arthritis, Lupus, and Autoimmune Disorders
Comparing Treatments in Children Newly Diagnosed with Crohn's Disease
The purpose of this study is to learn more about why some children with Crohn's disease heal their bowel inflammation after one type of treatment and why others do not. Volunteers must have suspected Crohn's disease.
Study Topics
Studying a Treatment for Patients with Severe Sjögren's Disease
Sjögren's disease is an autoimmune disorder that causes dry eyes and mouth. The purpose of this study is to learn about a new treatment for patients with this disease. We want to find out if the treatment, called nipocalimab, is safe and useful. To do this, we will compare the effects of nipocalimab to a placebo to see if it works.
Study Topics
Studying a New Medicine for Lennox-Gastaut Syndrome
Lennox-Gastaut Syndrome is a rare and serious kind of epilepsy that causes many types of seizures. The purpose of this study is to learn more about a medicine called EPX-100 to see if it helps people with this epilepsy. Our researchers want to find out how well the medicine works, what side effects it might have, and how it could help people in the future.
Study Topics
Testing a Device to Prevent Stroke in Patients with Patent Foramen Ovale
The purpose of this study is to test a new study device called the GORE CARDIOFORM Septal Occluder. We want to see if this device can help patients with this heart condition by closing the hole in the heart and preventing another stroke.
Study Topics
Studying a New Treatment Plan for Patients with Large B-cell Lymphoma or Grade IIIB Follicular Lymphoma
We are looking for volunteers with Grade IIIB Follicular or Relapsed/Refractory Diffuse Large B-cell Lymphoma. The purpose of this study is to see if we can reduce the chance of your cancer growing or spreading by adding more treatment to the usual therapy. We are doing this study to see if this new approach is better or worse than the usual approach for patients who are getting CAR T-cell therapy.
Study Topics
Studying Money Stress Among Patients with Leukemia
The purpose of this study is to see if helping people with money problems during cancer treatment can make them feel better and stay healthier. People in the study will answer questions about their health, feelings, and money. The goal is to find out if special help with money makes a difference.
Study Topics
Testing a New Heart Valve for Mitral Regurgitation
The purpose of this study is to test a new heart device called the Laminar System. We want to see if this device is safe and works well for people with a heart condition called non-valvular atrial fibrillation. The study will help doctors understand if this device can prevent strokes in these patients.
Study Topics
Testing a New Heart Device for Stroke Prevention
The purpose of this study is to test a new heart device called the Laminar System. We want to see if this device is safe and works well for people with a heart condition called non-valvular atrial fibrillation. The study will help doctors understand if this device can prevent strokes in these patients.
Study Topics
Comparing Bone Marrow Cancer Treatment Combinations
The purpose of this study is to find out which treatment works best for people who have just been diagnosed with multiple myeloma and cannot have a stem cell transplant. The study compares different combinations of medicines to see which helps people the most. Researchers hope this will help improve care for people with this type of cancer.
Study Topics
Studying a New Treatment Combination for Mantle Cell Lymphoma
The purpose of this study is to learn more about a new medicine combination to help patients with a type of blood cancer called mantle cell lymphoma. We want to see if a new medicine called sonrotoclax combined with the medicine zanubrutinib works better than zanubrutinib alone. Volunteers in the study will be randomly assigned to get either the new medicine or a placebo along with zanubrutinib.
Study Topics
Study of a New Medicine for Early Primary Myelofibrosis
Primary myelofibrosis is a rare, chronic blood cancer. The purpose of this study is to learn more about a new medicine for patients with early or low risk primary myelofibrosis. Our researchers want to see if the medicine is safe and works well for patients.
Study Topics
Studying Etentamig for Patients with Multiple Myeloma
The purpose of this study is to learn more about the medicine etentamig. We want to see if this medicine is safe and helpful for people with multiple myeloma. Our researchers will also study how the medicine works in the body, and what they learn may help improve future treatment for this cancer.
Study Topics
Using Brain Scans to Help Predict Brain Cancer Changes
The purpose of this study is to learn how different brain scans can show changes in brain cancer. The goal is to see if special MRI and PET scans can give doctors better information than regular scans. This may help doctors understand how tumors grow and how patients respond to treatment. This study is for volunteers with glioblastoma that is IDH‑wild type.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers
Studying New Treatments for Advanced Breast Cancer
The purpose of this study is to learn more about a new drug, MK-2870, alone or with another drug called pembrolizumab. We want to see how well they work compared to standard chemotherapy. The goal is to find out which treatment helps people live longer and feel better. This study is for volunteers with advanced breast cancer that cannot be removed by surgery.
Study Topics
Studying the Medicine Levosimendan for Heart and Lung Health
Pulmonary hypertension with heart failure with preserved ejection is a type of heart failure where the heart does not relax and fill with blood properly. This causes high pressure in the blood vessels in your lungs and makes it harder to breathe. The purpose of this study is to learn more about the medicine levosimendan for people with this condition. We want to see if this medicine can help people walk farther by improving heart and lung function.
Study Topics
Studying a New Medicine for Chronic Graft-Versus-Host Disease
Chronic graft-versus-host disease (cGVHD) is a condition where the donor's cells from a stem cell transplant attack the patient's body, thinking it is not their own. The purpose of this study is to learn more about a new medicine called vimseltinib to see if it is safe and helps people with this condition. The medicine may help by calming down the immune system. Researchers want to find the best dose with the fewest side effects.
Study Topics
Allergies and Immunity Skin, Hair, Nails Bones, Joints, Muscles