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Learning More About Muscle Mass and Cancer Treatment
The purpose of this study is to see if low muscle mass plays a role in the side effects from cancer treatment.
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Studying the Drug Linvoseltamab for Untreated Multiple Myeloma
The purpose of this study is to learn more about the study drug Linvoseltamab. We want to find out if this study drug is safe and helpful for treating patients with newly diagnosed multiple myeloma who have not had any treatment before. We also want to see how well patients can handle this drug.
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Using a New Drug, JNJ-79635322, to Treat Multiple Myeloma
The purpose of this study is to see if the study drug, JNJ-79635322 is safe and useful for treating patients with a type of cancer called Multiple Myeloma. This is the first time that the study drug is being given to humans. We want to learn more about any side effects and what amount works best.
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Treating Solid Tumors with Orotecan
The purpose of this study is to see if the study drug, JNJ-79635322 is safe and useful for treating patients with a type of cancer called Multiple Myeloma. This is the first time that the study drug is being given to humans. We want to learn more about any side effects and what amount works best.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Children, Teens Cancer: Solid Tumor
Studying the Drug STX-721 for Patients with Advanced Non-Small Cell Lung Cancer
The purpose of this study is to learn more about the study drug STX-72. We want to see if the study drug is safe and helpful for treating people with advanced non-small cell lung cancer. Volunteers must have a specific gene change related to EGFR or HER2.
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Learning More About Chronic Kidney Disease
The purpose of this study is to find out what helps kidneys stay healthy and what makes them stop working well. Our researchers will look at how kidney problems can affect the brain, behavior, heart, growth, and overall health. We hope to learn more about how to make medical care better for kids, teenagers and young adults.
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Studying New Medicines for Inflammatory Bowel Disease
Inflammatory Bowel Disease is a condition that causes swelling and pain in the digestive tract, making it hard for your body to digest food normally. The purpose of this study is to compare new medicines for this condition. Our researchers want to see if the medicines are safe and helpful for people who did not get better with other treatments.
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Understanding Sleep Patterns Among Children and Young Adults with Cancer
The purpose of this study is to learn more about how sleep changes in children and young adults during and after cancer treatment. Our researchers want to understand when sleep problems start and how to treat them. The goal is to improve sleep and overall health during cancer care. We are looking for volunteers who were recently diagnosed with cancer and plan to receive cancer therapy.
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Studying a New Medicine to Treat Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy is a disease that makes the heart muscle too thick which can make it harder for the heart to pump blood. The purpose of this study is to learn more about a new medicine for this disease called EDG-7500. We want to see if this medicine is safe and useful to treat patients.
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Studying a New Treatment for Virus After Transplant
Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV/PTLD) is a virus that can happen after receiving a solid organ transplant or allogenic cell transplant. The purpose of this study is to learn more about a new treatment called tabelecleucel. We want to see how well this treatment works for patients with this virus who did not get better with a treatment called rituximab or rituximab plus chemotherapy.
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Studying the Medicine JCAR017 for Blood Cancers
The purpose of this study is to learn more about the study medicine JCAR017. We want to see if this medicine is safe and useful for treating adults with a type of blood cancer called B-cell Chronic Lymphocytic Leukemia (CLL), and Small Lymphocytic Lymphoma (SLL) that has come back or has not responded to treatment.
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Studying the Medicine NBTXR3 for Head and Neck Cancer
The purpose of this study is to find out if a new medicine, given with radiation, helps people with head and neck cancer who cannot get certain chemotherapy. The study will also check if the medicine is safe. Doctors will compare the new medicine plus radiation to radiation alone.
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Studying What Concerns Care Teams about Immune Therapy for Transplants
The purpose of this study is to learn what makes doctors decide if they should use a certain cancer treatment in people who have had organ transplants and serious skin cancer. We will survey patients, doctors, and ethics experts (people who help others figure out what is right or wrong when making tough decisions). If you join the study, you will be asked to take a survey about your thoughts on a certain type of cancer treatment.
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Testing Different Treatment Doses for Newly Diagnosed Multiple Myeloma
Multiple myeloma is a type of cancer that starts in white blood cells. It is usually treated with drugs called isatuximab, lenalidomide, and dexamethasone. This study aims to test a lower dose of these drugs for people who are newly diagnosed with multiple myeloma. We want to see if the lower dose is safe and helpful.
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Treating Hodgkin Lymphoma with Combination Immuno-oncology Therapy
The purpose of this study is to compare the effects, good and/or bad, of the study drugs, brentuximab vedotin and nivolumab (Bv-NIVO), to the usual treatment for people with Hodgkins Lymphoma to find out which is better.
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Studying a New Medicine to Keep Depression Away
The purpose of this study is to find out if a new medicine, taken with current antidepressants, can help stop depression from coming back. Our researchers will also look at how safe the medicine is and what side effects it may cause. Volunteers who join the study will have regular checkups and answer questions about their health and feelings. We are looking for volunteers who have been diagnosed with major depressive disorder that has not improved with their current treatment.
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Studying the Medicine Triapine with Radiation for Recurrent Brain Tumors
The purpose of this study is to find out if adding a medicine called triapine to radiation therapy is safe for people with brain tumors that have come back. Our researchers will study different amounts of triapine to see which is safest. The goal is to learn if this new treatment works better or worse than usual care.
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Studying a Mobile App for Heart Rehab Post-Valve Procedure
The purpose of this study is to find out if an at home mobile app can help improve heart health. The app is a heart rehab program and involves a health exercise program. Volunteers in the study will be put into one of three groups: no app, using the app for 12 weeks, or using the app for 24 weeks. We are looking for volunteers who have recently had, or will soon have, a heart valve procedure to fix their aortic, mitral, or tricuspid valve.
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Studying Radiation Plus Immune Therapy for Kidney Cancer
The purpose of this study is to see if adding radiation to immune therapy helps people with kidney cancer that has spread. We want to see if this new treatment keeps the cancer from getting worse longer than immune therapy alone. The goal is to find out which treatment works better. We are looking for volunteers with kidney cancer that has spread, and surgery is not currently recommended.
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Using CTX001 to Treat Severe Sickle Cell Disease in Children
The purpose of this study is to learn more about using the study drug, CTX001, to treat sickle cell disease in children. We want to see how effective it is and if there are any side effects.
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