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Testing a New Heart Valve for Mitral Regurgitation
The purpose of this study is to test a new device called the AltaValve System. We want to see if it can help treat leaky heart valves. We want to find out if the device is safe and works well for people who cannot have open-heart surgery. The study is for adults with mitral valve regurgitation.
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Learning More about Immunotherapy Before and After Skin Cancer Surgery
The purpose of this study is to learn about a new way to treat skin cancer with surgery. We want to see if giving a type of medicine called immunotherapy before and after surgery helps people stay cancer-free longer than the usual treatment. We are trying to find out if this new way works better or worse than the regular way. We are looking for volunteers who have a kind of skin cancer called cutaneous squamous cell carcinoma that can be removed with surgery.
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Using Sonrotoclax to Treat Cancer
The purpose of this study to see how well the anticancer study drug currently known as sonrotoclax works in the treatment of a type of cancer called Waldenström's Macroglobulinemia.
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A Study of the Drug ABBV-383 for Treatment of Multiple Myeloma
Multiple myeloma is a type of blood cancer. The purpose of this study is to find out if the study drug ABBV-383 can be safely used with other treatments for this type of cancer. We want to find out the safest dose of the study drug when combined with these treatments. We also want to see if these combinations help patients whose cancer has returned or didn't respond to previous treatments.
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Studying a New Cancer Treatment for Patients with Blood Cancer
The purpose of this study is to learn more about a new treatment for patients with blood cancer. We want to see if the treatment called AZD0486 when used alone or with other cancer treatment, is safe and useful. We are looking for volunteers with a one of these types of blood cancers: mantle cell lymphoma, chronic lymphocytic leukemia, or small lymphocytic lymphoma. The study team will provide more information.
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Using MRI to Protect the Brain in Lung Cancer Patients
This study is about finding out if using brain scans alone, instead of brain scans plus preventive brain radiation, affects how long people with small cell lung cancer live.
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Studying the Drug REGN5678 for Patients with Prostate Cancer
The purpose of this study is to learn more about a treatment for patients with prostate cancer. We want to see if the study drug called REGN4336 is safe and useful for patients with castration-resistant prostate cancer that has spread to other parts of the body. Study team will provide more information.
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Studying Vitamin C Levels and Blood Cancer Treatment Outcomes
The purpose of this study is to see if vitamin C levels affect how well treatments work for people with certain types of blood cancer. We will also look at specific genes that might affect vitamin C in the body. This study will help us understand if vitamin C can improve treatment results for these cancers. We are looking for volunteers with acute myeloid leukemia, myelodysplastic syndromes, or chronic myelomonocytic leukemia.
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Studying Diabetes Medicine for Heart and Kidney Health
The purpose of this study is to learn more about two types of diabetes medicines. We want to see which medicine type helps lower the risk of heart and kidney problems. We are looking for volunteers with type 2 diabetes and a history of heart disease or have high risk for heart disease that are patients of Elizabeth Internal Medicine and Carmel Family Physicians.
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Treating Neuroendocrine Carcinoma with Atezolizumab
The purpose of this study is to see if adding the study drug, atezolizumab, to the usual cancer treatment helps people with a type of cancer that starts outside the lungs called neuroendocrine carcinoma.
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Testing the Study Drug KTX-1001 for The Treatment of Multiple Myeloma
The goal of this study is to learn more about the study drug KTX-1001. We want to find out if this drug is safe for patients with multiple myeloma that has returned or didn't respond to treatment. We also want to see if patients can handle the taking the drug.
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Testing the Study Drug PRO1160 for Advanced Kidney, Throat, and Blood Cancers
The purpose of this study is to learn more about the new drug PRO1160. We want to see if it is safe and helpful for treating patients with cancer that didn't fully respond to treatment or has come back. Volunteers must have kidney cancer, throat cancer, or a type of blood cancer called non-Hodgkin lymphoma.
Study Topics
Cancer Cancer: Ear, Nose, Mouth, Throat Cancer: Kidney, Liver, Pancreas Cancer: Lymphoma
Treating Hyperactivity in Children with Down Syndrome using Guanfacine
The purpose of this study is to learn more about how well the study drug, guanfacine, can treat hyperactivity in children with Down syndrome.
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A Study of the Drug Efruxifermin for Treating Liver Diseases and Scarring of the Liver
Non-alcoholic steatohepatitis and metabolic dysfunction-associated steatohepatitis are types of fatty liver disease that cause scarring of the liver. We want to learn more about the safety and effects when using the study drug Efruxifermin to treat these diseases.
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Learning More About the Neuroguard IEP Direct System for Treatment of Carotid Artery Narrowing
The purpose of this study is to learn more about a new study device called the Neuroguard IEP Direct System to treat patients with narrowed arteries in their neck that supply blood to their brain. The treatment involves making a small cut on one side of your neck to place the device.
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A Study of the Drug Lutikizumab for Treatment of Ulcerative Colitis
The purpose of this study is to learn more about the study drug Lutikizumab. We want to see if this study drug is safe and effective for treatment of ulcerative colitis. We also want to compare this study drug to the current drug Adalimumab.
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Using Technology to Improve Care for Teens with Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) affects the digestive system. Types of IBD include Ulcerative Colitis and Crohn's disease. The purpose of this study is to find out if text messaging can be used to help care for people with IBD. Volunteers must have a smartphone with text messaging.
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Electromagnetic Treatment for Stroke Recovery
The purpose of this study is to see if a wearable device helps stroke recovery. The device uses low-frequency electromagnetic fields to activate the brain. Volunteers must have had stroke onset 4 to 21 days ago.
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A Study of the Drug Efruxifermin for Patients with Liver Disease
The goal of this study is to find out if a drug called efruxifermin can help people with liver scarring caused by liver disease. We also want to know if the drug is safe and helpful for patients. Volunteers must have a liver disease where too much fat builds up, causing inflammation and scarring. Study team will provide more information.
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