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Testing the Study Drug Olvi-Vec for Ovarian Cancer that Resists Treatment
The purpose of this study is to learn about the drug Olvi-Vec. We want to see if it is safe and helpful for treating ovarian, fallopian tube, or peritoneal cancer that did not get better with a type of treatment called platinum-based chemotherapy.
Study Topics
A Study of the Drug Acalabrutinib for Mantle Cell Lymphoma Treatment
The purpose of this study is to learn more about the study drug Acalabrutinib. We want to see if this study drug can be effective for mantle cell lymphoma when combined with the standard of care treatment. We also want to find out the side effects of this study drug.
Study Topics
Tracking Medtronic Device Results
The purpose of this study is to collect information on how Medtronic devices work over time. We want to improve the safety and performance of these devices. The study is for volunteers who has or is intended to receive or be treated with, an eligible Medtronic product. The study team will provide more information.
Study Topics
Testing the Study Drug Daratumumab Treatments for AL Amyloidosis
Amyloid light chain amyloidosis is a disease where bad proteins build up in organs and tissues, making them not work right. The purpose of this study is to learn more about the study drug daratumumab for the treatment of this disease. We want to see if the study drug is safe and helpful for treating this disease.
Study Topics
Comparing Treatments for Severe Aplastic Anemia in Young People
The purpose of this study is to find out whether immune suppressive therapy or bone marrow transplant is better for treating a disease called severe aplastic anemia in young patients who don't have a matched sibling donor.
Study Topics
Rare Disease Cancer Cancer: Blood Cancer: Children, Teens Children, Infants, Teen Health
Studying the Drug SNDX-5613 for Patients with Acute Myeloid Leukemia
The study aims to learn more about the drug SNDX-5613. We want to find the best dose for patients with a blood cancer called acute myeloid leukemia. We also want to see how this drug works when used with two other drugs, daunorubicin and cytarabine.
Study Topics
Studying a Medicine for Babies with Alagille Syndrome
The purpose of this study is to learn more about a medicine called Odevixibat for babies with Alagille Syndrome. We want to see if this medicine can safely help reduce itching in babies with this health condition.
Study Topics
Genetic Disorders Rare Disease Children, Infants, Teen Health
Studying Blood Particles to Help Treat Cancer
The purpose of this study is to learn more about tiny particles in the blood called extracellular vesicles. By studying this, we hope to find out more about different types of cancer and how to treat them better. We will look at the blood samples from patients with similar cancers to see if we can discover new information. This could help doctors choose the best treatments for cancer patients in the future. We are looking for volunteers with urothelial, prostate, or kidney cancer. The study team will provide more information.
Study Topics
Using Levocarnitine to Protect the Liver During Chemotherapy
The study aims to find out if the study drug, levocarnitine, can reduce severe liver damage caused by chemotherapy in patients with certain cancers.
Study Topics
Kidneys, Liver, Pancreas Cancer Cancer: Leukemia Cancer: Lymphoma
Testing New Treatments for Multiple Myeloma
The purpose of this study is to test a new mix of drugs for people with a type of blood cancer called multiple myeloma. We want to see if adding a new drug, belantamab mafodotin, to the usual treatment of carfilzomib, lenalidomide, and dexamethasone works better. This study will help doctors find out if this new mix helps patients live longer and feel better.
Study Topics
Studying a New Blood Test for Patients with Blood Cancer
The purpose of this study is to create a new blood test for patients with blood cancer. We want to see if this new blood test can help predict which patients will benefit from a type of immunotherapy called CAR T-cell therapy. We are looking for volunteers with blood cancer that are eligible to receive CAR T-cell therapy. The study team will provide more information.
Study Topics
Cancer Cancer: Blood Cancer: Leukemia Cancer: Lymphoma Cancer: Myeloma
Testing the Study Drug Tegavivint for Advanced Liver Cancer
An autoimmune cytopenia is a condition when your immune system, which usually fights germs, accidentally attacks your own blood cells. This study wants to find out if the study drug ALPN-303 is safe and helpful for treating this condition.
Study Topics
Using Zanubrutinib to Treat Lymphoma
The purpose of this study is to see if the study drug, zanubrutinib, works better than the current treatment. The study will compare how well the new drug works, how safe it is, and how it affects the quality of life of the participants.
Study Topics
Testing the Study Drug Tegavivint for Advanced Liver Cancer
The purpose of this study is to learn more about the study drug tegavivint. We want to see if this study drug is safe and useful to treat patients with liver cancer. Volunteers must be diagnosed with liver cancer that cannot be removed surgery and is worsening. Study team will provide more information.
Study Topics
Using Ide-Cel to Treat Multiple Myeloma
The purpose of this research is to see if idecabtagene vicleucel (ide-cel) is safe and useful to treat participants with multiple myeloma.
Study Topics
Using Tagraxofusp to Treat Cancer in Young People
The purpose of this study is to see if adding the study drug, Tagraxofusp, to the usual treatment helps people with refractory (difficult to treat) and/or relapsed (cancer that has returned after previous treatment) hematologic malignancy (cancer). We also want to learn more about any side effects of the study drug.
Study Topics
Testing the Drugs Inavolisib and Phesgo for Advanced Breast Cancer Treatment
This study aims to learn about a new drug combination for breast cancer that has spread. We want to compare the side effects of the drugs inavolisib and Phesgo with a placebo and Phesgo. Volunteers must have HER2-positive PICK3CA-mutated breast cancer, study team will provide more details.
Study Topics
Testing the Addition of chemotherapy to Hormonal Therapy for Breast Cancer
The purpose of this study is to compare two commonly used treatment choices for early-stage breast cancer in premenopausal women. We want to know if adding chemotherapy to hormonal therapy helps people with breast cancer.
Study Topics
Testing a New Weekly HIV Treatment for People with HIV-1
The goal of this study is to find out more about a new way to treat HIV. We want to see if taking one pill of islatravir with the drug lenacapavir once a week is safe, easy to take, and works well. We also want to know if this is better than taking the usual medicine every day.
Study Topics
Treating Vulvar Dysplasia with a New Surgical Treatment
This study is being done to see if a surgical treatment, Frozen-Section Directed Excision, is better at treating vulvar dysplasia than the usual treatment.
Study Topics