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Finding Muscle Changes in Myotonic Dystrophy Patients
Myotonic dystrophy (DM) is a disease that causes muscles to weaken and waste away. The purpose of this study is to find the best ways to measure muscle weakness and changes in patients with DM using MRI scans. Understanding these changes will help plan future studies to track the disease and test new treatments. We are seeking healthy volunteers as well as volunteers who have been diagnosed with myotonic dystrophy.
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A Study of the Drug Volrustomig for Head and Neck Cancer Treatment
The study wants to learn about a drug called Volrustomig. It aims to find out if this drug is safe and helpful for people with head and neck cancer that hasn't been taken out and has spread to nearby areas. The drug will be given after patients finish their chemotherapy and radiation treatments.
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Using Body Fat Images to Assess Health
The purpose of this study is to see if we can use medical images of fat throughout the body to assess your health status.
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Aging Healthy Volunteers Heart Health Weight, Metabolism, Nutrition
Comparing Methods to Test for Anal Cancer and HPV
The purpose of this study is to compare three methods of collecting anal swabs for testing HPV and anal cancer. These methods include patients collecting swabs at home, patients collecting swabs in a clinic, and healthcare workers collecting swabs. The goal is to determine if all three methods provide the same results. We are looking for volunteers who are at high risk for anal cancer and meet the screening criteria for anal dysplasia.
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Studying a New Way to Prevent Blood Clots During Medical Procedures
The goal of this study is to help people who need medical procedures where their blood goes outside their body, like during dialysis or heart surgery. We want to find a way to stop blood clots during these procedures. This study will help us learn how to prevent clots and make these procedures safer. We are looking for healthy volunteers, both adults and children, who are 17-70 years old and weigh over 110 pounds.
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New Migraine Medicine for Teens
The purpose of this study is to learn more about a new medicine called Rimegepant to help teenagers with chronic migraine. We want to see if this medicine is safe and useful to prevent chronic migraine.
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Improving Physical Function in Older Adults with Kidney Disease
The purpose of this study is to find out if two different programs can help older people with chronic kidney disease. One program involves exercise with quick movements 3 times per week for 12 weeks, and the other program involves taking classes on how to live a healthy lifestyle once per week for 12 weeks. Our researchers want to see if older people enjoy these programs and if they can be done safely. We are looking for volunteers who live within 20 miles of the Reynolda Campus.
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Studying How Stress Affects Health in People Living with HIV
Many people living with HIV disease have stress in their lives that can negatively affect their health. The goal of this study is to understand how long-term stress changes how our brain and immune systems work. We also want to see how these changes affect our feelings, thoughts, and actions. By learning this, we hope to create better treatments for problems like depression and drug use. The study is open to individuals living with HIV.
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Improving COPD Care for Cancer Patients
Chronic obstructive pulmonary disease (COPD) is a lung disease that makes it hard to breathe because the airways are swollen and narrow. The purpose of this study is to create a new way to help cancer patients who also have COPD. We want to make their treatment easier and improve their care. Our study will look at how well this new care plan works.
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Studying Hair Loss in Women of African Descent during Chemotherapy
The purpose of this study is to understand hair loss in African American women who are getting chemotherapy for breast cancer. We want to find out how common different types of hair loss are with chemotherapy. We also want to learn about the participants' health history, medical information, and hair styling habits.
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Minority Health Skin, Hair, Nails Women's Health Cancer Cancer: Breast
Learning More About Treating Myelofibrosis and Anemia with the Study Drug DISC-0974
Myelofibrosis is a rare blood disorder that can cause scar tissue to build up in the bone marrow. This can lead to anemia. Anemia can result in tiredness and general discomfort. The purpose of this study is to see who well the study drug DISC-0974 works for the treating myelofibrosis and anemia. We also want to learn more about the side effects the study drug may cause.
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Studying the Long-Term Usefulness of a Parkinson's Disease Treatment
The purpose of this study is to see how well the drug ABBV-951 works for people with advanced Parkinson's Disease over a long time. We will look at how the drug affects movement, daily activities, and changes in the disease over three years. We need volunteers who have never taken the drug before or who have used it before. The study team will give more details.
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Testing New Ulcerative Colitis Treatment
The purpose of this study is to learn more about a new study drug called Lutikizumab. We want to see if this study drug is safe and works well for treating moderate to severe ulcerative colitis. We will compare this study drug to another drug called Adalimumab.
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Arthritis, Lupus, and Autoimmune Disorders Stomach and Intestines
Studying Two Treatments for Early Stage Breast Cancer
The purpose of this study is to learn more about adding chemotherapy to hormone treatment for breast cancer. We will compare two common treatments to see which works better. The goal is to find out if adding chemotherapy can prevent the cancer from returning and learn more about the possible side effects. We are looking for volunteers who have early-stage breast cancer, are HER2-negative, and have not gone through menopause yet.
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Studying a New Weight Loss Medicine for Overall Health Among Older Adults
The purpose of this study is to learn more about a weight loss medicine called tirzepatide. We want to see how this medicine affects body fat, bones, and how well older adults can move. Volunteers in the study will take the medicine and join sessions about healthy eating and exercise. The goal is to see if the drug helps improve health in older adults who are overweight or obese.
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Men's Health Weight, Metabolism, Nutrition Wellness and Lifestyle Women's Health
Testing a New App for Radiation Skin Rash in Head and Neck Cancer Patients
We want to learn about a new mobile app called MyCap for people with head and neck cancer who are getting radiation therapy. The study will check if the app can collect information about skin rashes caused by radiation. Volunteers will need to use their own mobile device to access the app. You are invited to join this study because you have head and neck cancer and will get radiation therapy.
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Testing a New Treatment for Muscle Weakness
The purpose of this study is to test a new treatment called YTB323 for people with generalized myasthenia gravis. We want to see if YTB323 is safe and helps improve muscle strength. Participants will receive the treatment through an IV infusion.
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Neurology Disorders Arthritis, Lupus, and Autoimmune Disorders Bones, Joints, Muscles
Comparing Metformin and Insulin for Gestational Diabetes
The purpose of this study is to see if the medicine Metformin works as well and is as safe as insulin for treating diabetes during pregnancy. We also want to know which treatment pregnant people with diabetes like better and how it affects their pregnancy.
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Studying a New Bladder Pain Treatment
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a condition that causes pain in the bladder and makes you feel like you need to pee often, even if your bladder is not full. The purpose of this study is to learn more about a new medicine called VNX001 for this condition. Our researchers want to learn if it is safe and works well for patients.
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A Study of the Drug Seladelpar for Liver Disease and Scarring of the Liver
The purpose of this study is to learn more about the study drug Seladelpar. We want to see if the study drug can help treat patients with chronic liver disease and scarring of the liver. We will look at changes in overall health, severity of symptoms, and progression of disease.
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