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Learning More About Chronic Kidney Disease
The purpose of this study is to find out what helps kidneys stay healthy and what makes them stop working well. Our researchers will look at how kidney problems can affect the brain, behavior, heart, growth, and overall health. We hope to learn more about how to make medical care better for kids, teenagers and young adults.
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Studying the Drug STX-721 for Patients with Advanced Non-Small Cell Lung Cancer
The purpose of this study is to learn more about the study drug STX-72. We want to see if the study drug is safe and helpful for treating people with advanced non-small cell lung cancer. Volunteers must have a specific gene change related to EGFR or HER2.
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Studying New Medicines for Inflammatory Bowel Disease
Inflammatory Bowel Disease is a condition that causes swelling and pain in the digestive tract, making it hard for your body to digest food normally. The purpose of this study is to compare new medicines for this condition. Our researchers want to see if the medicines are safe and helpful for people who did not get better with other treatments.
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Studying a New Medicine to Treat Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy is a disease that makes the heart muscle too thick which can make it harder for the heart to pump blood. The purpose of this study is to learn more about a new medicine for this disease called EDG-7500. We want to see if this medicine is safe and useful to treat patients.
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Understanding Sleep Patterns Among Children and Young Adults with Cancer
The purpose of this study is to learn more about how sleep changes in children and young adults during and after cancer treatment. Our researchers want to understand when sleep problems start and how to treat them. The goal is to improve sleep and overall health during cancer care. We are looking for volunteers who were recently diagnosed with cancer and plan to receive cancer therapy.
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Studying a New Treatment for Virus After Transplant
Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV/PTLD) is a virus that can happen after receiving a solid organ transplant or allogenic cell transplant. The purpose of this study is to learn more about a new treatment called tabelecleucel. We want to see how well this treatment works for patients with this virus who did not get better with a treatment called rituximab or rituximab plus chemotherapy.
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Studying the Medicine NBTXR3 for Head and Neck Cancer
The purpose of this study is to find out if a new medicine, given with radiation, helps people with head and neck cancer who cannot get certain chemotherapy. The study will also check if the medicine is safe. Doctors will compare the new medicine plus radiation to radiation alone.
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Studying the Medicine JCAR017 for Blood Cancers
The purpose of this study is to learn more about the study medicine JCAR017. We want to see if this medicine is safe and useful for treating adults with a type of blood cancer called B-cell Chronic Lymphocytic Leukemia (CLL), and Small Lymphocytic Lymphoma (SLL) that has come back or has not responded to treatment.
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Using MRI to Protect the Brain in Lung Cancer Patients
This study is about finding out if using brain scans alone, instead of brain scans plus preventive brain radiation, affects how long people with small cell lung cancer live.
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Studying What Concerns Care Teams about Immune Therapy for Transplants
The purpose of this study is to learn what makes doctors decide if they should use a certain cancer treatment in people who have had organ transplants and serious skin cancer. We will survey patients, doctors, and ethics experts (people who help others figure out what is right or wrong when making tough decisions). If you join the study, you will be asked to take a survey about your thoughts on a certain type of cancer treatment.
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Testing Different Treatment Doses for Newly Diagnosed Multiple Myeloma
Multiple myeloma is a type of cancer that starts in white blood cells. It is usually treated with drugs called isatuximab, lenalidomide, and dexamethasone. This study aims to test a lower dose of these drugs for people who are newly diagnosed with multiple myeloma. We want to see if the lower dose is safe and helpful.
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Studying a New Medicine to Keep Depression Away
The purpose of this study is to find out if a new medicine, taken with current antidepressants, can help stop depression from coming back. Our researchers will also look at how safe the medicine is and what side effects it may cause. Volunteers who join the study will have regular checkups and answer questions about their health and feelings. We are looking for volunteers who have been diagnosed with major depressive disorder that has not improved with their current treatment.
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Studying the Medicine Triapine with Radiation for Recurrent Brain Tumors
The purpose of this study is to find out if adding a medicine called triapine to radiation therapy is safe for people with brain tumors that have come back. Our researchers will study different amounts of triapine to see which is safest. The goal is to learn if this new treatment works better or worse than usual care.
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Treating Hodgkin Lymphoma with Combination Immuno-oncology Therapy
The purpose of this study is to compare the effects, good and/or bad, of the study drugs, brentuximab vedotin and nivolumab (Bv-NIVO), to the usual treatment for people with Hodgkins Lymphoma to find out which is better.
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