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Adding Naxitamab to the Usual Treatment for Neuroblastoma
The purpose of this study is to find out how well Naxitamab works for treating neuroblastoma. Naxitamab will be given along with the usual treatment.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Rare Cancers
Treating Head and Neck Cancer with Cetuximab
The purpose of this study is to see how well the drug Cetuximab works for treating head/neck cancer that stopped responding to treatment. It is possible that Cetuximab may work better when given in patients who have already had immunotherapy.
Study Topics
Study of DSP-5336 for Treatment of Leukemia
Acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and acute leukemia are types of cancer of the blood and bone marrow. This study will help us learn more about a new drug, DSP-5336, that is being tested for treatment of AML, ALL and acute leukemia. The purpose of this study is to find out how safe DSP-5336 is at different doses.
Study Topics
Study of Canakinumab for Treating Myelofibrosis
The purpose of this study is to find out how well Canakinumab works for treating myelofibrosis.
Study Topics
Study of Second Look Laparoscopy with Hyperthermic intraperitoneal chemotherapy (HIPEC) in Patients with Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma
After their first surgery, patients often have a procedure called second look reassessment surgery. This surgery allows doctors to look inside your body and check for signs of cancer. The purpose of this study is to see how well it works to give HIPEC during the second look surgery. HIPEC is a type of chemotherapy inserted directly into your abdomen at the time of surgery. We want to monitor any effects that this has on your health.
Study Topics
Women's Health Cancer Cancer: Rare Cancers Cancer: Women's Cancer
Finding Out How Well Selinexor Works for Treating Brain Cancer
The purpose of this study is to find the safest dose of the study drug, Selinexor. We also want to find out if adding the study drug is better than the usual treatment for brain cancer.
Study Topics
Study of Selinexor for Treating High-Grade Glioma in Pediatric Patients
A glioma is a type of cancer that occurs in the brain or spine. Diffuse intrinsic pontine glioma is a type of high-grade glioma. The purpose of this study is to look at how well selinexor works when given to children and young adults with high-grade glioma or diffuse intrinsic pontine glioma. We also want to find the highest dose of selinexor that we can give safely along with radiation therapy.
Study Topics
Cancer Cancer: Brain, Nervous System, Spinal Cord Children, Infants, Teen Health
Finding Therapies that Improve Survival for Patients with Glioblastomas
The purpose of this research is to test multiple study treatments for glioblastoma. We want to find out if any of these study treatments can improve how long patients live.
Study Topics
Using Cancer Cells in the Blood to Determine the Type of Chemotherapy that Will Benefit Colon Cancer Patients After Surgery
The purpose of this study is to help us learn more about using circulating tumor DNA (ctDNA) results to decide what chemo to offer patients after colon cancer surgery. ctDNA is DNA that has been released from tumor cells into your blood. Finding ctDNA in your blood means that there are likely small amounts of cancer after surgery. This study will help us find out if using ctDNA results to decide on treatment is better than the usual approach.
Study Topics
Adding Radiation Therapy to the Usual Treatment for Small Cell Lung Cancer
This study is being done to find out if we can slow lung cancer from growing or spreading. We will try to do this by adding radiation therapy to the usual treatment.
Study Topics
Testing the Addition of Radiation Therapy to the Usual Treatment for Advanced Stage Non-small Cell Lung Cancer
The purpose of this study is to find out if we can lower the chance of lung cancer growing or spreading by adding radiation therapy. The radiation therapy will be given along with the usual treatment. We want to find out if this approach is better or worse than the usual approach for lung cancer.
Study Topics
Treating Multiple Myeloma with Study Drug ABBV-383
The purpose of this study is to see how the study drug, ABBV-383, affects patients with multiple myeloma that has returned or been difficult to treat. Some volunteers will get increasing doses of the study drug. We want to see if the increasing doses can reduce a side effect known as cytokine release syndrome.
Study Topics
Study of Quick Start Durvalumab for Treating Stage III Non-Small Cell Lung Cancer
Durvalumab is usually started 30 days or more after radiation treatment. The purpose of this study is to find out if it is possible to start Durvalumab within 14 days after radiation treatment. We want to see how the quick start affects you and your cancer.
Study Topics
Treating Prostate Cancer with Omeprazole and Chemotherapy
The purpose of this study is to find out how Omeprazole may help treat prostate cancer. It will be given along with chemotherapy. Researchers believe Omeprazole may help the chemotherapy work.
Study Topics
Testing a New Treatment Routine for Patients with Pancreatic Cancer
The purpose of this study is to test a new treatment routine for patients with pancreatic cancer. We want to see how well it works to give two different chemotherapy regimens one after the other.
Study Topics
Testing the Combination of Abemaciclib and Olaparib for Treatment of Ovarian Cancer
The purpose of this study is to learn more about using abemaciclib and olaparib to treat ovarian cancer that has returned. This study tests different doses of the drugs to find the highest dose that is safe and well tolerated. We also want to see what side effects may occur.
Study Topics
Study of the Effectiveness of the Drug Mosunetuzumab with Lenalidomide, Compared to the Drug Rituximab with Lenalidomide in Patients with Follicular Lymphoma
The purpose of this study is to compare the effects, good or bad, of mosunetuzumab administered in combination with lenalidomide versus rituximab administered in combination with lenalidomide in patients with follicular lymphoma (FL). FL is a type of cancer that affects white blood cells, which are part of the body's immune system.
Study Topics
Testing the Addition of a Third Medication to the Usual Treatment for Gastroesophageal Adenocarcinoma
The purpose of this study is to find out if the drug irinotecan can extend life after the diagnosis of cancer in the stomach, esophagus, or gastroesophageal junction. Irinotecan will be added to the usual treatment. We want to find out if this approach is better or worse than the usual treatment.
Study Topics
Testing Different Courses of Hormone Therapy Depending on the Type of Prostate Cancer
The purpose of this study is to test different courses of hormone therapy depending on the type of prostate cancer. We are doing this study to find out if these approaches are better, similar, or worse than the usual approach for your type of prostate cancer.
Study Topics
Comparing Single Dose to Multiple Doses of Radiation for Patients with Cancer that Has Spread to the Brain
The purpose of this study is to find out if there are less side effects when radiation therapy is given to small areas of brain cancer over several days compared to one day. We want to find out if this approach is better or worse than the usual approach.
Study Topics