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Comparing Two Different Methods of Surgery to Treat Osteosarcoma that Has Spread to the Lungs
The purpose of this study is to compare two different surgery methods for people with osteosarcoma that has spread to the lung. We want to find out which surgery method is better. One method is called open thoracic surgery. It is done through a single large cut between the ribs, opens the chest, and removes the cancer. The other method is called thoracoscopy. It is done through several small incisions and uses a small camera to help with removing the cancer. Both methods are considered standard treatment.
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Adding Tazemetostat to the Usual Treatment for Melanoma
The purpose of this study is to find out if the study drug, tazemetostat, can keep your melanoma from getting worse. We also want to see if the study drug alone is better or worse than adding the study drug to the usual treatment.
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Adding the Study Drug Apalutamide to the Usual Treatment for Prostate Cancer After Surgery
The purpose of this study is to find out if we can extend the time without your prostate cancer spreading by adding the study drug to the usual treatment. We want to find out if this approach is better or worse than the usual approach for your prostate cancer.
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Learning More About Adding TRC102 to the Usual Non-Small Cell Lung Cancer Treatment
The purpose of this study is to learn more about the study drug, TRC102. We want to see how it can affect Stage III lung cancer. TRC102 will be added to the usual treatment. The addition of TRC102 to the usual treatment could stabilize your cancer and lengthen the time you can live. This study will help the us find out if this approach is better than the usual approach.
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Treating Multiple Myeloma with Study Drug ABBV-383
The purpose of this study is to see how the study drug, ABBV-383, affects patients with multiple myeloma that has returned or been difficult to treat. Some volunteers will get increasing doses of the study drug. We want to see if the increasing doses can reduce a side effect known as cytokine release syndrome.
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Study of Quick Start Durvalumab for Treating Stage III Non-Small Cell Lung Cancer
Durvalumab is usually started 30 days or more after radiation treatment. The purpose of this study is to find out if it is possible to start Durvalumab within 14 days after radiation treatment. We want to see how the quick start affects you and your cancer.
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Testing the Combination of Abemaciclib and Olaparib for Treatment of Ovarian Cancer
The purpose of this study is to learn more about using abemaciclib and olaparib to treat ovarian cancer that has returned. This study tests different doses of the drugs to find the highest dose that is safe and well tolerated. We also want to see what side effects may occur.
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Comparing Single Dose to Multiple Doses of Radiation for Patients with Cancer that Has Spread to the Brain
The purpose of this study is to find out if there are less side effects when radiation therapy is given to small areas of brain cancer over several days compared to one day. We want to find out if this approach is better or worse than the usual approach.
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Comparing Two Surgical Procedures to Reduce the Risk of Ovarian Cancer
The purpose of this study is to compare two different surgeries to reduce the risk of ovarian cancer. The study will look at the process used to decide which surgery is best for the patient. It will also look at symptoms that occur after removal of the ovaries.
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Using Camizestrant for Hormone Therapy to Treat ER+/HER2- Breast Cancer
The purpose of this study is to learn more about the study drug camizestrant. We want to see how well the study drug works at stopping the cancer from coming back compared to the usual treatment.
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Using Ultrasound to Detect Neuropathy Caused by Chemotherapy with Oxaliplatin
The purpose of this study is to find out if ultrasound can be used to diagnose damage to nerves caused by the drug Oxaliplatin. Taking part in this study requires one visit. The visit will include ultrasound of the nerve, nerve conduction test, skin biopsy, and examination of your nerves.
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Finding Better Ways to Diagnose, Treat and Prevent Cancer in Children
The purpose of creating the database is to help find better ways to diagnose, treat and prevent cancer in children.
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Understanding How to Best Care for Patients in the Brain Tumor Clinic
This study will collect information from patients seen in the Brain Tumor Clinic at Wake Forest Baptist Comprehensive Cancer Center. The database will include the patient's symptoms, condition and response to treatment. The data will be used to understand how we can best care for patients seen in our clinic.
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Study of the Drug BI 1831169 in People with Different Types of Advanced Solid Tumors
The purpose of this study is to find the best dose of the study drug, BI 1831169, for patients with advanced solid tumors. We also want to see how well the study drug may work and what side effects it may cause.
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Studying What Causes Bone Pain
The purpose of this research study is to understand what causes bone pain. We will create and test different ways to study bone pain. We are looking for adults with cancer who will have a bone test (biopsy) or surgery to remove bone tissue at the Winston-Salem campus of Atrium Health Wake Forest Baptist Medical Center.
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Study of the Drug Inotuzumab Ozogamicin in Patients with Disseminated B-cell Lymphoblastic Lymphoma
The purpose of this study is to find out if the study drug, Inotuzumab Ozogamicin, can help treat certain types of leukemia. The study drug will be given along with the usual chemotherapy.
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Adding High Dose Radiation to the Usual Treatment for Non-Small Cell Lung Cancer
The purpose of this study is to find out if we can delay your cancer getting worse and help you live longer by giving high-dose radiation therapy directly to your lung tumor. This treatment will be done before the usual treatment for locally-advanced non-small cell lung cancer. We want to find out if this approach is better or worse than the usual treatment.
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A Study of the Drug ABBV-383 for Patients with AL Amyloidosis
The purpose of this study is to learn more about the study drug ABBV-383 in patients with amyloidosis. We want to find the best dose and learn about the safety and effects of the study drug.
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Testing a New Treatment for Myeloproliferative Disorders
The purpose of this study is to see how well the study drug, INCA033989, works for treating myeloproliferative disorders. We want to find what effects, if any, this therapy may have on people. We also want to find out what is the highest dose that can be given without causing severe side effects.
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Study of the Drug AMG 355 in Patients with Advanced Solid Tumors
The purpose of this study is to learn more about the study drug AMG 355. We want to see how well the study drug works for treating advanced solid tumors. We also want to learn more about the side effects that may be caused by the study drug.
Study Topics
Cancer Cancer: Colon, Rectum, Anus Cancer: Lung Cancer: Skin Cancer: Stomach and Intestines