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Learning More About Using ABBV-383 to Treat Amyloidosis
The purpose of this study is to find out how safe and effective the study drug, ABBV-383, is in treating people with with amyloidosis.
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Learning More About Using Ivonescimab to Treat Lung Cancer
The purpose of this research study is to see if the study drug, ivonescimab, is safe and useful to treat people with a type of cancer called metastatic squamous non-small cell lung cancer.
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Studying a New Cancer Therapy for Advanced Solid Tumors
X-PACT is a new cancer treatment that uses a drug called psoralen and a low dose of X-rays. This study wants to see if this treatment is safe and helpful for patients. Volunteers need to have advanced head and neck cancer, soft tissue sarcoma, breast cancer, melanoma, or other solid tumors that didn't get better with other treatments.
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Cancer Cancer: Breast Cancer: Head, Neck Cancer: Sarcoma (Bone, Muscle, Soft Tissue) Cancer: Skin Cancer: Solid Tumor
Testing a New Drug Combination for Patients with Myelofibrosis
The purpose of this study is to learn more about using two drugs called navtemadlin and ruxolitinib. We want to see if taking both drugs together helps treat patients with myelofibrosis. We also want to see if people can handle taking the drugs.
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Testing the Study Drug BCA101 for Advanced Solid Tumors
The goal of this study is to learn more about a drug called BCA101. We want to find out if this drug is safe and if it can help people with cancer that has come back or spread after treatment. This study is for volunteers who have solid tumors, like head and neck cancer, colorectal cancer, lung cancer, and other types. Study team will provide more information.
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Using the Study Drugs Atezolizumab and Bevacizumab to Treat Liver Cancer
The study wants to learn more about a drug called Atezolizumab. We want to see how well it treats liver cancer by itself and when used with another drug called Bevacizumab. We also want to know if these treatments are better or worse than the usual treatment. Volunteers must have advanced liver cancer that can't be removed by surgery.
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Using Ziftomenib to Treat Myeloid Leukemia
The purpose of this study is to see if the study drug, Ziftomenib, combined with other treatments is safe and useful to treat people with myeloid leukemia.
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Learning More About Muscle Mass and Cancer Treatment
The purpose of this study is to see if low muscle mass plays a role in the side effects from cancer treatment.
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Studying the Drug Linvoseltamab for Untreated Multiple Myeloma
The purpose of this study is to learn more about the study drug Linvoseltamab. We want to find out if this study drug is safe and helpful for treating patients with newly diagnosed multiple myeloma who have not had any treatment before. We also want to see how well patients can handle this drug.
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Treating Solid Tumors with Orotecan
This study is being done to see how safe the study drug, Orotecan, is and how well it will work to treat solid tumors and brain tumors that have returned or have not gotten better with the usual treatment.
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Cancer Cancer: Brain, Nervous System, Spinal Cord Cancer: Children, Teens Cancer: Solid Tumor
Using a New Drug, JNJ-79635322, to Treat Multiple Myeloma
The purpose of this study is to see if the study drug, JNJ-79635322 is safe and useful for treating patients with a type of cancer called Multiple Myeloma. This is the first time that the study drug is being given to humans. We want to learn more about any side effects and what amount works best.
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Studying the Drug STX-721 for Patients with Advanced Non-Small Cell Lung Cancer
The purpose of this study is to learn more about the study drug STX-72. We want to see if the study drug is safe and helpful for treating people with advanced non-small cell lung cancer. Volunteers must have a specific gene change related to EGFR or HER2.
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Understanding Sleep Patterns Among Children and Young Adults with Cancer
The purpose of this study is to learn more about how sleep changes in children and young adults during and after cancer treatment. Our researchers want to understand when sleep problems start and how to treat them. The goal is to improve sleep and overall health during cancer care. We are looking for volunteers who were recently diagnosed with cancer and plan to receive cancer therapy.
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Studying a New Treatment for Virus After Transplant
Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV/PTLD) is a virus that can happen after receiving a solid organ transplant or allogenic cell transplant. The purpose of this study is to learn more about a new treatment called tabelecleucel. We want to see how well this treatment works for patients with this virus who did not get better with a treatment called rituximab or rituximab plus chemotherapy.
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Studying the Medicine NBTXR3 for Head and Neck Cancer
The purpose of this study is to find out if a new medicine, given with radiation, helps people with head and neck cancer who cannot get certain chemotherapy. The study will also check if the medicine is safe. Doctors will compare the new medicine plus radiation to radiation alone.
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Studying the Medicine JCAR017 for Blood Cancers
The purpose of this study is to learn more about the study medicine JCAR017. We want to see if this medicine is safe and useful for treating adults with a type of blood cancer called B-cell Chronic Lymphocytic Leukemia (CLL), and Small Lymphocytic Lymphoma (SLL) that has come back or has not responded to treatment.
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Studying What Concerns Care Teams about Immune Therapy for Transplants
The purpose of this study is to learn what makes doctors decide if they should use a certain cancer treatment in people who have had organ transplants and serious skin cancer. We will survey patients, doctors, and ethics experts (people who help others figure out what is right or wrong when making tough decisions). If you join the study, you will be asked to take a survey about your thoughts on a certain type of cancer treatment.
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Testing Different Treatment Doses for Newly Diagnosed Multiple Myeloma
Multiple myeloma is a type of cancer that starts in white blood cells. It is usually treated with drugs called isatuximab, lenalidomide, and dexamethasone. This study aims to test a lower dose of these drugs for people who are newly diagnosed with multiple myeloma. We want to see if the lower dose is safe and helpful.
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Treating Hodgkin Lymphoma with Combination Immuno-oncology Therapy
The purpose of this study is to compare the effects, good and/or bad, of the study drugs, brentuximab vedotin and nivolumab (Bv-NIVO), to the usual treatment for people with Hodgkins Lymphoma to find out which is better.
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Studying the Medicine Triapine with Radiation for Recurrent Brain Tumors
The purpose of this study is to find out if adding a medicine called triapine to radiation therapy is safe for people with brain tumors that have come back. Our researchers will study different amounts of triapine to see which is safest. The goal is to learn if this new treatment works better or worse than usual care.
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